Calcifediol Monohydrate Chemical Properties

Flash point:

14℃

storage temp. 

-20°C

solubility 

Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in fatty oils.

color 

White to Light yellow

BRN 

4270041

InChIKey

JWUBBDSIWDLEOM-LCDSLSDMSA-N

SMILES

C[C@]12CCC/C(=C\C=C3\C[C@@H](O)CCC\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)CCCC(O)(C)C.O |&1:1,10,16,20,22,r|

CAS DataBase Reference

63283-36-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

T+

Risk Statements 

28-48/25-26-24/25

Safety Statements 

28-36/37-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

F 

8-10-19

HS Code 

29362900

MSDS

• Language:English Provider:SigmaAldrich

Calcifediol Monohydrate Usage And Synthesis

Chemical Properties

White or almost white crystals.

Uses

Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It is produced in the liver and is the best indicator of the body’s vitamin D stores. It is effective in the treatment of ricket

Uses

25-Hydroxyvitamin D3 may be used as a certified reference material (CRM) for the determination of the analyte in biological samples by chromatography techniques.

Definition

ChEBI: Calcifediol monohydrate is a vitamin D.

brand name

Calderol (Organon).

General Description

A Certified Spiking Solution^? of 25-Hydroxyvitamin D3, a prohormone whose blood serum levels are used to determine Vitamin D nutritional status. This solution standard is suitable for critical quantitative applications in research and clinical environments including: for use in preparation of controls and calibrators for LC/UV and LC-MS/MS assays; as system tuning/suitability standards; linearity verification; internal proficiency testing; and for OEM use in preparation of reagents, development of assays and instrument IQ/OQ. The stable, quantitative solution format provides significant benefits to the user including material savings, increased efficiency of labor, and convenience of use. The shelf stable Snap-N-Spike^? format allows laboratories to eliminate painstaking weighing operations and provides the ability to spike a known concentration of analyte into their matrix of choice just before use.

Biochem/physiol Actions

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 25-dihydroxycholecalciferol is a the major circulating form of vitamin D3 and a physiological precursor of 1α,25-Dihydroxycholecalciferol. The conversion is catalyzed by 25-Hydroxyvitamin D3 1-α-hydroxylase (VD3 1A hydroxylase) also known ascytochrome p450 27B1 (CYP27B1).

target

IL Receptor

Dosage

Calcidiol monohydrate contains the monohydrate form of the major circulating metabolite of vitamin D3 in the body and is a source of 1,25-dihydroxyvitamin D, the biologically active form of vitamin D. Calciferol monohydrate (25-hydroxycholecalciferol monohydrate) is safe under recommended conditions and level of use (up to 10 μg/day) and is safe for children >11 years of age and adults, including pregnant and lactating women.

Calcifediol Monohydrate(63283-36-3)Related Product Information

• Tocopheryl acetate
• Vitamin D2
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• VITAMIN E NICOTINATE
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• CALCIFEDIOL
• Calcifediol Monohydrate
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• CALCIFEDIOL - REFERENCE SPECTRUM
• 24(R), 25-DIHYDROXYVITAMIN D3
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• calcifediol lactone
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• 1ALPHA,25-DIHYDROXY[26,27-METHYL-3H]-CHOLECALCIFEROL