Emedastine Chemical Properties

Boiling point:

446.6±55.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 125 mg/mL (413.35 mM); Ethanol: 100 mg/mL (330.68 mM)

pka

8.86±0.10(Predicted)

CAS DataBase Reference

87233-61-2(CAS DataBase Reference)

Emedastine Usage And Synthesis

Uses

Antihistaminic, H1-receptor; asthma prophylactic; anti-allergic.

Definition

ChEBI: 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the ifumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.

brand name

Emadine (Alcon).

Clinical Use

Emedastine also is a newer antihistamine used topically in the eye for conjunctivitis. It has very high H1 receptor selectivity characteristics, and it is structurally related to the benzimidazoles, such as astemizole. Inhibition of mast cell release of inflammatory mediators has been noted.

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