Gastric Mucin Chemical Properties

storage temp. 

2-8°C

solubility 

1 M NaOH: soluble20mg/mL

form 

partially purified powder

color 

Off-white to light yellow

biological source

Porcine stomach

Safety Information

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:SigmaAldrich

Gastric Mucin Usage And Synthesis

Description

Mucins are high-molecular-weight glycoproteins expressed throughout the gastrointestinal tract, with a key role in mucosal protection and function. In gastric cancer expression of MUC5AC and MUC1 is reduced and denovo expression of MUC2 occurs.

Chemical Properties

It is white to yellow-white powder or yellow-brown granule with peptone-like odor and salty taste. Strong hygroscopicity, swelling in water, the aqueous solution is gray or milky white, it does not precipitate when it meets heat, and it is precipitated when it meets weak acid, and it can be precipitated by more than 60% ethanol or acetone in the solution. It can be precipitated by more than 60% ethanol or acetone in solution. It can be decomposed into various proteins and polysaccharides by acid for a long time.

Uses

Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.

General Description

Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus. It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.

Biological Activity

Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin-17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients.

Biochem/physiol Actions

Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.

Gastric Mucin(84082-64-4)Related Product Information

• SALCOMINE
• Tosylmethyl isocyanide
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• N-BUTYLISOCYANIDE
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• Tris(2,4-pentanedionato)chroMiuM(III)
• TERT-BUTYL ISOCYANIDE
• Ethyl isocyanoacetate
• COBALT(II) ACETYLACETONATE
• PHENYLSELENOL
• METHYL ISOCYANOACETATE
• Cupric acetylacetonate
• Ferric acetylacetonate
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• Aluminum acetylacetonate
• Benzyl isocyanide