2-AMINO-4-CHLORO-6-NITROTOLUENE Chemical Properties

Boiling point:

333.4±37.0 °C(Predicted)

Density 

1.415±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

1.08±0.10(Predicted)

Appearance

Yellow to orange Solid

Safety Information

HS Code 

2921490090

2-AMINO-4-CHLORO-6-NITROTOLUENE Usage And Synthesis

Synthesis

4-Iodo-2,6-dinitrotoluene (5.9 g, 23.60 mmol) was used as raw material and dissolved in a solvent mixture of methanol (10 mL) and 1,4-dioxane (5 mL). Under ice bath cooling conditions, 10 N hydrochloric acid (12 mL) and iron powder (3.96 g, 70.80 mmol) were slowly added. The reaction mixture was stirred at 80 °C for 3 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until complete conversion of the feedstock. Upon completion of the reaction, 3.55 g of the light yellow powdery product 2-amino-4-chloro-6-nitrotoluene was obtained in 68.4% yield.

References

[1] Patent: CN108689937, 2018, A. Location in patent: Paragraph 0069; 0070; 0073; 0074
[2] Patent: CN108689936, 2018, A. Location in patent: Paragraph 0070; 0072; 0076; 0077
[3] Patent: US2010/63066, 2010, A1. Location in patent: Page/Page column 36
[4] Journal of the Chemical Society, 1905, vol. 87, p. 1265
[5] Patent: US5952362, 1999, A

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