L(+)-Homoarginine hydrochloride
L(+)-Homoarginine hydrochloride Basic information
- Product Name:
- L(+)-Homoarginine hydrochloride
- Synonyms:
-
- L-HOMOARGININE HYDROCHLORIDE, UNNATU
- L-Homoarg.hcl
- L-(S)-2-AMINO-6-GUANIDINOHEXANOIC ACID HYDROCHLORIDE
- L(+)-HOMOARGININE HCL
- L-HOMOARGININE HCL
- L(+)-HOMOARGININE HYDROCHLORIDE
- L-HOMOARGININE HYDROCHLORIDE
- L-HOMOARGININE MONOHYDROCHLORIDE
- CAS:
- 1483-01-8
- MF:
- C7H17ClN4O2
- MW:
- 224.69
- EINECS:
- 216-045-6
- Product Categories:
-
- Aliphatics
- Inhibitors
- Amino Acids & Derivatives
- Nitric Oxide Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Homoarginine [HomoArg]
- Amino Acids 13C, 2H, 15N
- Mol File:
- 1483-01-8.mol
L(+)-Homoarginine hydrochloride Chemical Properties
- Melting point:
- 213-215 °C(lit.)
- alpha
- 18 º (c=1, 1N HCl)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- H2O: 50 mg/mL, clear to slightly hazy, faintly yellow
- form
- Granular Powder
- color
- White
- Water Solubility
- Soluble in water(50 mg/mL).
- BRN
- 4016621
- Stability:
- Moisture Sensitive
- CAS DataBase Reference
- 1483-01-8(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36/37/39-27-26
- WGK Germany
- 3
- HS Code
- 29252900
MSDS
- Language:English Provider:L(+)-Homoarginine hydrochloride
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
L(+)-Homoarginine hydrochloride Usage And Synthesis
Description
L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.
Chemical Properties
White Powder
Uses
An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).
Uses
An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.
Biochem/physiol Actions
Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.
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L(+)-Homoarginine hydrochloride(1483-01-8)Related Product Information
- ARGINASE
- L(+)-Arginine
- Homoarginine
- Topotecan hydrochloride
- 6-Aminocaproic acid
- L-Arginine hydrochloride
- Glycine
- Boc-N'-Nitro-L-homoarginine
- FMOC-HOMOARG(PMC)-OH
- N-ALPHA-T-BUTOXYCARBONYL-L-HOMOARGININE HYDROCHLORIDE,Boc-L-Homoarginine hydrochloride
- arginine aspirin
- D-Homoarginine hydrochloride
- 6-GUANIDINOHEXANOIC ACID
- FMOC-HOMOARG-OH
- Fmoc-N-Pbf-L-HomoArginine
- FMOC-L-HOMOARGININE, HYDROCHLORIDE SALT
- BOC-HOMOARG(ET)2-OH
- Z-HOMOARG-OH