CARNOSOL Chemical Properties

Melting point:

240～242℃

Boiling point:

524.8±50.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM)

form 

Solid

pka

8.91±0.40(Predicted)

color 

White

LogP

2.832 (est)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29322090

Hazardous Substances Data

5957-80-2(Hazardous Substances Data)

CARNOSOL Usage And Synthesis

Description

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Description

Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC₅₀ = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC₅₀ = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.

Chemical Properties

White powder

Uses

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Definition

ChEBI: Carnosol is a diterpenoid.

Cytotoxicity

IC₅₀ (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC₅₀ (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC₅₀ (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC₅₀ (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).

CARNOSOL(5957-80-2)Related Product Information

• CARNOSOL
• Carnosic acid
• 1-PHENYL-1-CYCLOHEXANECARBOXYLIC ACID
• cyclomenol
• 1-(4-Methylphenyl)-1-cyclohexanecarboxylic acid
• 2 [PARA ISOPROPYL PHENYL] PROPIONALDEHYDE
• 2-CYCLOHEXYL-5-METHYLPHENOL
• ethyl 2-(4-ethylphenyl)acetate
• pisiferic acid
• CARNOSOL(NOW AVAILABLE IN GRAM SIZES)(P),CARNOSOL(P)
• Carnosol, Rosmarinus officinalis
• tetrahydro-3-pentyl-2H-pyran-2-one
• 4-(1-METHYLETHYL)-BENZENEACETIC ACID METHYL ESTER
• ethyl 4-isopropylphenylacetate
• (1-phenylcyclohexane)methanol
• DEHYDROABIETINE
• 1-Phenylcyclohexane-1-carbaldehyde
• 3-ISOPROPYL-6-METHYLCATECHOL