Danofloxacin mesylate Chemical Properties

Melting point:

337-339°C

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

Aqueous Base (Slightly, Sonicated), DMSO (Slightly, Sonicated)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

CAS DataBase Reference

119478-55-6(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HS Code 

29339900

Danofloxacin mesylate Usage And Synthesis

Description

Danofloxacin is a fluoroquinolone antibiotic and a type II topoisomerase inhibitor. It has a broad antimicrobial spectrum. It can be used as an anti-infective agent for veterinary use only.

Brand Name(s) in US

Advocin

Reference

J. A. Schrickx, J. Fink-Gremmels, Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters, British Journal of Pharmacology, 2009, vol. 150, pp. 463-469

Description

Danofloxacin is a fluoroquinolone antibiotic. In vitro, danofloxacin has activity against 68 field isolates of Mycoplasma species isolated from cattle, swine, and poultry with MICs ranging from 8 to 500 nM. It is protective in vivo against P. multocida, E. coli, and S. choleraesuis in mice with protective doses of 0.31, 0.40, and 2.42 mg/kg, respectively. Formulations containing danofloxacin are widely used to prevent infectious disease in livestock.

Chemical Properties

Crystalline Solid

Uses

Danofloxacin is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM

Uses

Fluorinated quinolone antibacterial.

Definition

ChEBI: Danofloxacin mesylate is a member of quinolines.

Veterinary Drugs and Treatments

Danofloxacin mesylate injection is indicated for the treatment of Bovine Respiratory Disease (BRD) associated with Mannheimia (Pasturella) hemolytica and P. multocida in cattle (not dairy or veal). Because of the drug’s spectrum of activity, it may also be of benefit in the treatment of infections caused by Histophilus somni (Haemophilus somnus) or M. bovis, but the drug is not labeled (at the time of writing) for treating these pathogens. In other countries, danofloxacin may be labeled for use in swine and chickens (non-laying), but in the USA it is illegal to use the drug in an extralabel manner in food-producing species.
Danofloxacin may be of benefit in treating susceptible infections in adult horses, camelids and other non-food producing species.

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