Ethyl thiophene-3-carboxylate Chemical Properties

Boiling point:

97-98 °C (8 mmHg)

Density 

1.12

refractive index 

1.509-1.511

Flash point:

103 °C

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Water Solubility 

Soluble in water.

Safety Information

Safety Statements 

24/25-23

HS Code 

29349990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl thiophene-3-carboxylate Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Ethyl thiophene-3-carboxylate is used as an intermediate in organic syntheses

Synthesis

Thirteen mL (200 mmol) of thionyl chloride was added slowly and dropwise at 0 °C to a 100 mL ethanol solution containing 9 g (70 mmol) of 3-thiophenecarboxylic acid and 86 mg (0.7 mmol) of 4-dimethylaminopyridine. The reaction mixture was gradually warmed from 0 °C to room temperature over 48 h with continuous stirring. Subsequently, the reaction solution was evaporated to dryness. The resulting residue was purified by silica column chromatography with the eluent being a 1:1 heptane/dichloromethane solvent mixture. Finally 10 g (91% yield) of ethyl thiophene-3-carboxylate was obtained.

References

[1] Patent: WO2004/113331, 2004, A1. Location in patent: Page 38-39
[2] Organic Process Research and Development, 2017, vol. 21, # 7, p. 947 - 955
[3] Organic Letters, 2008, vol. 10, # 9, p. 1851 - 1854
[4] Angewandte Chemie - International Edition, 2017, vol. 56, # 33, p. 9924 - 9929
[5] Angew. Chem., 2017, vol. 129, p. 10056 - 10061,6

Ethyl thiophene-3-carboxylate(5751-80-4)Related Product Information

• Ethyl acetate
• Ethanol
• Ethyl acrylate
• Ethyl formate
• Methyl acrylate
• ISOXADIFEN-ETHYL
• Benzocaine
• Trinexapac-ethyl
• Thiophene
• Ethyl cyanoformate
• Ethyl cyanoacetate
• Ethylparaben
• Urethane
• Triethyl orthoformate
• Tris(trimethylsilyl)phosphate
• RESMETHRIN
• Dimethyl thiophene-2,3-dicarboxylate
• 2-Thiophenecarboxaldehyde