Dibutyl sebacate Chemical Properties

Melting point:

205 °C (dec.)(lit.)

Boiling point:

178-179 °C3 mm Hg(lit.)

Density 

0.94

vapor pressure 

0.001Pa at 25℃

FEMA 

2373 | DIBUTYL SEBACATE

refractive index 

n20/D 1.441(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

hexane, toluene, ethanol and acetone: soluble

form 

Liquid

Specific Gravity

0.937 (20/4℃)

color 

Clear

Odor

at 100.00 %. faint fruity oily

Odor Type

fruity

Water Solubility 

50mg/L(temperature not stated)

JECFA Number

625

BRN 

1798308

Dielectric constant

4.5（30℃）

LogP

6.30

CAS DataBase Reference

109-43-3(CAS DataBase Reference)

NIST Chemistry Reference

Di-n-butyl sebacate(109-43-3)

EPA Substance Registry System

Dibutyl sebacate (109-43-3)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

40-36/37/38

Safety Statements 

36/37-36-26

WGK Germany 

3

RTECS 

VS1150000

TSCA 

Yes

HS Code 

29171390

Hazardous Substances Data

109-43-3(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 14870mg/kg

MSDS

• Language:English Provider:Dibutyl sebacate
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Dibutyl sebacate Usage And Synthesis

Description

Dibutyl sebacate is a colorless oily liquid. Insoluble in water, soluble in alcohol, miscible with oils. Poorly soluble in Propylene glycol.Fruity, but very mild and oily odor of considerable tenacity.

Chemical Properties

clear liquid

Chemical Properties

Dibutyl sebacate is a clear, colorless, oily liquid with a bland to slight butyl odor.

Uses

Dibutyl sebacate (DBS) is a dibutyl ester of sebacic acid. Dibutyl sebacate can be used for plastics in use in the food packaging industry, in plastics used for medical devices, and for pharmaceutical applications. Dibutyl sebacate is also used as a desensitizer in Otto fuel II, a torpedo monopropellant.

Uses

Dibutyl sebacate has been used as a plasticizer to prepare free ethylcellulose films. It can be utilized as a core in liquid-core capsules with cross-linked alginate/polyacrylamide membrane prepared via co-extrusion jet-break-up method for the extraction of the pesticide, atrazine.

Definition

ChEBI: Dibutyl decanedioate is a fatty acid ester.

Production Methods

Dibutyl sebacate is manufactured by the esterification of n-butanol and sebacic acid in the presence of a suitable catalyst, and by the distillation of sebacic acid with n-butanol in the presence of concentrated acid.

Preparation

By distillation of sebacic acid with butyl alcohol in the presence of concentrated HCl in benzene solution or by reacting butyl alcohol and sebacyl chloride

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dibutyl sebacate is a commonly used plasticizer, which can be synthesized by the reaction of butyl alcohol and sebacyl chloride or by the distillation of sebacic acid with butyl alcohol in the presence of concentrated hydrochloric acid in benzene solution.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Dibutyl sebacate is used in oral pharmaceutical formulations as a plasticizer for film coatings on tablets, beads, and granules, at concentrations of 10–30% by weight of polymer. It is also used as a plasticizer in controlled-release tablets and microcapsule preparations.
Dibutyl sebacate is also used as a synthetic flavor and flavor adjuvant in food products;for example,up to 5ppm is used in ice cream and nonalcoholic beverages.

Safety Profile

Mddly toxic by ingestion. Experimental reproductive effects. Combustible liquid when exposed to heat or flame; can react with oxidzing materials. To fight fire, use CO2 position it emits acrid smoke and fumes. See also ESTERS and n-BUTYL. ALCOHOL.

Safety

Dibutyl sebacate is used in cosmetics, foods, and oral pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. Following oral administration, dibutyl sebacate is metabolized in the same way as fats. In humans, direct eye contact and prolonged or repeated contact with the skin may cause very mild irritation. Acute animal toxicity tests and long-term animal feeding studies have shown no serious adverse effects to be associated with orally administered dibutyl sebacate.
LD50 (rat, oral): 16g/kg

storage

Dibutyl sebacate should be stored in a closed container in a cool, dry location. Dibutyl sebacate is stable under the recommended storage conditions and as used in specified applications under most conditions ofuse.Asanester,dibutylsebacatemayhydrolyzeinthe presence of water at high or low pH conditions.

Incompatibilities

Dibutyl sebacate is incompatible with strong oxidizing materials and strong alkalis.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, granules, film-coated, sustained action, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Dibutyl sebacate(109-43-3)Related Product Information

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