Hederagenin
Hederagenin Basic information
- Product Name:
- Hederagenin
- Synonyms:
-
- HEDERAGENIN(RG)
- (3β,4α) -3,23-Dihydroxy-olean-12-en- 28-oic acid
- CAULOSAPOGENIN
- HEDERAGENIN
- 3,23-DIHYDROXYOLEAN-12-EN-28 OIC ACID
- (3-beta,4-alpha)-3,23-dihydroxyolean-12-en-28-oicacid
- 3,23-dihydroxy-,(3-beta,4-alpha)-olean-12-en-28-oicaci
- 3-beta,23-dihydroxy-olean-12-en-28-oicaci
- CAS:
- 465-99-6
- MF:
- C30H48O4
- MW:
- 472.71
- EINECS:
- 207-369-9
- Product Categories:
-
- Saponins
- Pentacyclic Triterpenes
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Detergent
- Mol File:
- 465-99-6.mol
Hederagenin Chemical Properties
- Melting point:
- 332-334°
- alpha
- D20 +81° (c = 0.7 in pyridine)
- Boiling point:
- 493.44°C (rough estimate)
- Density
- 0.9871 (rough estimate)
- refractive index
- 1.4800 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- methanol: soluble1mg/mL
- pka
- 4.63±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
- λmax
- 405nm(H2SO4)(lit.)
- Merck
- 14,4624
- InChIKey
- PGOYMURMZNDHNS-MYPRUECHSA-N
- LogP
- 7.410 (est)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 22
- Safety Statements
- 22-45-24/25
- WGK Germany
- 3
- HS Code
- 29181990
MSDS
- Language:English Provider:Hederagenin
Hederagenin Usage And Synthesis
Description
Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
Chemical Properties
White Solid
Uses
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
Definition
ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).
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