7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Chemical Properties

Melting point:

115 °C

Boiling point:

456.1±45.0 °C(Predicted)

Density 

1.46±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

DMSO (Slightly)

pka

1.95±0.20(Predicted)

form 

Solid

color 

Yellow to Beige

Stability:

Hygroscopic

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Usage And Synthesis

Uses

JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.

Definition

ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.

Biological Activity

Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .

References

[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN(62252-26-0)Related Product Information

• GAMMA-SECRETASE INHIBITOR
• 2-(Chloromethyl)benzoic acid
• 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
• Methyl 2-chloromethylbenzoate
• 1H-2-Benzopyran-1-one
• 3-METHOXY-1H-ISOCHROMEN-1-ONE
• BENZOIC ACID, 5-AMINO-2-METHYL-, METHYL ESTER, HYDROCHLORIDE
• 1,1-DIMETHOXYETHENE