Basic information Description References Safety Supplier Related
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Thiamine hydrochloride

Basic information Description References Safety Supplier Related

Thiamine hydrochloride Basic information

Product Name:
Thiamine hydrochloride
Synonyms:
  • VIT B1
  • VITAMIN B1 HCL
  • VITAMIN B1 HYDROCHLORIDE
  • TIMTEC-BB SBB001377
  • THIAMINE
  • THIAMINE CHLORIDE HYDROCHLORIDE
  • THIAMINE HCL
  • THIAMINE HYDROCHLORIDE
CAS:
67-03-8
MF:
C12H17N4OS.ClH.Cl
MW:
337.27
EINECS:
200-641-8
Product Categories:
  • Nutritional supplement.
  • Inhibitors
  • Biochemistry
  • Amines
  • Vitamin B1
  • vitamin
  • Vitamins and derivatives
  • Vitamin Ingredients
  • Miscellaneous Compounds
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Vitamins
Mol File:
67-03-8.mol
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Thiamine hydrochloride Chemical Properties

Melting point:
250 °C (dec.)(lit.)
Density 
1.3766 (rough estimate)
FEMA 
3322 | THIAMINE HYDROCHLORIDE
refractive index 
1.6000 (estimate)
Flash point:
9°C
storage temp. 
room temp
solubility 
H2O: 0.1 g/mL at 20 °C, clear, colorless
form 
Crystalline Powder
pka
pKa 4.8 (Uncertain);9.0 (Uncertain)
color 
White to almost white
PH
2.7-3.3
Water Solubility 
1 g/mL
Sensitive 
Light Sensitive & Hygroscopic
Merck 
14,9295
JECFA Number
1030
BRN 
3851771
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents.
CAS DataBase Reference
67-03-8(CAS DataBase Reference)
EPA Substance Registry System
Thiamine hydrochloride (67-03-8)
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Safety Information

Hazard Codes 
Xi,T,F
Risk Statements 
36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
22-24/25-37/39-26-36-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
RTECS 
XI7350000
3-8-10
TSCA 
Yes
HS Code 
29362200
Toxicity
LD50 in mice (mg/kg): 89.2 i.v.; 8224 orally (Winter)

MSDS

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Thiamine hydrochloride Usage And Synthesis

Description

Thiamine Hydrochloride is the hydrochloride salt form of thiamine (vitamin B1), a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Vitamin B1 helps prevent various health problems including heart damage.
Thiamine hydrochloride is used to prevent and treat thiamine deficiency states, which may occur as a result of inadequate nutrition or intestinal malabsorption. It is also used for the treatment of Wernicke-Korsakoff syndrome, beriberi and thiamine deficiency related to chronic alcoholism. Thiamine hydrochloride is used as a food additive to add brothy/meaty flavor to gravies or soups. It is used also as a food supplement and flavoring ingredient with a bitter taste.

References

[1] https://www.drugs.com
[2] Shmuel Yannai (2012) Dictionary of Food Compounds with CD-ROM, Second Edition
[3] https://www.medicines.org.uk

Description

In 1912, Cashmir Funk isolated thiamine from rice husks and coined the term ‘vitamine’ because it was required for life (‘vita’) and because thiamine contained nitrogen (‘amine’). Thiamine, formerly known as B1, is water soluble. Thiamine is a vital cofactor for enzymes and coenzymes of glycolysis, the Kreb’s cycle, the pentose phosphate pathway. Thiamine is also involved in the biosynthesis of the neurotransmitters acetylcholine and gamma-aminobutyric acid and in nerve propagation.

Chemical Properties

White or almost white, crystalline powder or colourless crystals.

Chemical Properties

Vitamin B1 has an odor slightly reminiscent of thiazole and a bitter taste. When exposed to air, the vitamin rapidly absorbs about 4% of water.

Occurrence

Rice husks are reportedly the principal source of vitamin B1; in variable amounts it is a constituent of yeast, milk, green leaves, roots and tubers; it is also present in high concentration in seeds, and in lesser amount in different animal organs and muscles.

Uses

Thiamine is the water-soluble vitamin b1, required for normal digestion and functioning of nerve tissues and in the prevention of beriberi. It also acts as a coenzyme in the metabolism of carbohydrates. During processing, the higher and longer the heating period, the greater the loss. The loss is reduced in the presence of acid. Thiamine hydrochloride and thiamine mononitrate are two available forms. The mononitrate form is less hygroscopic and more stable than the hydrochloride form, making it suitable for use in beverage powders. It is used in enriched flour and is found as thiamine mononitrite in frozen egg substitute and crackers.

Uses

Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products , vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t o neurological impairment, bariberi, Wernicke-Korsakoff syndrome.

Uses

A cofactor required for oxidation of carbohydrates and for the synthesis of ribose.

Definition

ChEBI: A hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid.

Preparation

By linking the preformed thiazole and pyrimidine ring system.

General Description

Thiamine is a water-soluble vitamin of the B complex whose phosphate derivatives are involved in many cellular processes required for overall human health. Thiamine deficiency, often the result of impaired nutritional status associated with chronic diseases from alcoholism to HIV-AIDS, is monitored in patient whole blood samples by HPLC.

Health Hazard

Diseases and disorders resulting from a deficiency of thiamine include beriberi, opisthotonos (in birds), polyneuritis, hyperesthesia, bradycardia, and edema. Rather than a specific disease, beriberi may be described as a clinical state resulting from a thiamine deficiency. In body cells, thiamine pyrophosphate is required for removing carbon dioxide from various substances, including pyruvic acid.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. The vitamin is destroyed by alkalies and alkaline drugs such as phenobarbital sodium and by oxidzing and reducing agents. When heated to decomposition it emits very toxic fumes of HCl, Cl-, SOx, and NOx.

Environmental Fate

Thiamine and its common phosphate analogs are readily soluble in water and ubiquitously utilized in nature.

Purification Methods

The hydrochloride crystallises from 95% EtOH (solubility is ca 1%). The monohydrate is dehydrated at 100o in vacuo over H2SO4, but is hygroscopic and picks up one molecule of H2O readily. It can be sterilised at 100o if the pH of the solution is below 5.5. The nitrate has m 196-200o(dec) and is more stable than the hydrochloride. The picrolonate crystallises from H2O and is dimorphic, m 164-165o and 228-229o(dec). [Todd & Bergel J Chem Soc 364, 367 1937, J Am Chem Soc 58 1063, 1504 1936, 59 526 1937, Beilstein 27 IV 1766.]

Thiamine hydrochlorideSupplier

Brother Enterprises Holding Co., Ltd. Gold
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0573-87006335
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pharm@brother.com.cn
Wuhan DKY Technology Co.,Ltd. Gold
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27-81302411
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Taizhou Yuxin Biotechnology Co., Ltd., Gold
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0576-88902229
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yuxin@yuxchem.com
Wuhan Dingxintong Pharmaceutical Co. , Ltd.
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027-52344656
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15871722230@163.com
Tianjin Zhongxin Chemtech Co., Ltd.
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022-66880623;022-89880623
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sales@tjzxchem.com;sales@tjzxchem.com