L-Glutamic acid 5-tert-butyl ester
L-Glutamic acid 5-tert-butyl ester Basic information
- Product Name:
- L-Glutamic acid 5-tert-butyl ester
- Synonyms:
-
- L-Glutamic acid γ-t.-butyl ester
- Glu(OtBu)-OH
- L-Glutamic acid γ-tert·butyl ester monohydrate
- L-Glutamic acid 5-t-Butyl Ester
- GLUTAMIC ACID GAMMA-T-BUTYL ESTER MONOHYDRATE
- L-GLUTAMIC ACID-Y-T-BUTYL ESTER
- L-GLUTAMIC ACID-Y-T-BUTYLESTER MONOHYDRATE
- L-GLUTAMIC ACID .GAMMA.-TERT-BUTYL ESTER MONOHYDRATE
- CAS:
- 2419-56-9
- MF:
- C9H17NO4
- MW:
- 203.24
- EINECS:
- 607-337-8
- Product Categories:
-
- Amino Acids
- Glutamic acid [Glu, E]
- Amino Acids and Derivatives
- Amino Acid Derivatives
- Glutamic Acid
- Peptide Synthesis
- Mol File:
- 2419-56-9.mol
L-Glutamic acid 5-tert-butyl ester Chemical Properties
- Melting point:
- 182°C(lit.)
- Boiling point:
- 110 °C(Press: 0.05 Torr)
- Density
- 0.992 g/cm3
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Solid
- pka
- 2.20±0.10(Predicted)
- color
- White to Almost white
- Water Solubility
- Sparingly soluble in water; practically insoluble in ethanol or ether.
- BRN
- 2049031
- Major Application
- peptide synthesis
- InChI
- InChI=1S/C9H17NO4/c1-9(2,3)14-7(11)5-4-6(10)8(12)13/h6H,4-5,10H2,1-3H3,(H,12,13)/t6-/m0/s1
- InChIKey
- OIOAKXPMBIZAHL-LURJTMIESA-N
- SMILES
- C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)N
- CAS DataBase Reference
- 2419-56-9(CAS DataBase Reference)
Safety Information
- Risk Statements
- 22-24
- Safety Statements
- 22-24/25-25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29224999
- Storage Class
- 11 - Combustible Solids
MSDS
- Language:English Provider:SigmaAldrich
L-Glutamic acid 5-tert-butyl ester Usage And Synthesis
Chemical Properties
White powder crystal
Uses
L-Glutamic acid 5-tert-butyl ester is used as a fine chemical intermediate, pharmaceutical intermediate.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
In a 3000mL three-necked flask, 2324g of tert-butyl acetate and 73.5g of glutamic acid were added, stirred, and was added dropwise. 160.8 mL of perchloric acid, react for 48 hours at 10??C, cool down to 0??C, add 1000 mL of water, extract (the remaining tert-butyl acetate was used as solvent extraction), neutralized with Na2CO3 to pH=8 to 9, partitioned, and then extracted with 400 mL of 1% Na2CO3 aqueous solution was washed three times, and the tert-butyl acetate layer was concentrated under reduced pressure to give 42 g of Glu(OtBu)2 as an oil in 32.4% yield.
In a 1000 mL three-necked flask, 42 g of Glu(OtBu)2 was added, 400 mL of water and 11 g of CuCl2 were added, . The temperature was raised to 50 ??C and the reaction was carried out for 12 h to produce Cu[Glu(OtBu)]x (x=1-2); then it was lowered to room temperature and was added 19g tetramethylethylenediamine and 100mL dioxane, and then adjust the pH to 8~9 with triethylamine to produce L-glutamic acid-5-tert-butyl ester.
L-Glutamic acid 5-tert-butyl ester Preparation Products And Raw materials
Preparation Products
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L-Glutamic acid 5-tert-butyl ester(2419-56-9)Related Product Information
- L-Glutamic acid
- BUTYL OLEATE
- Butyl acetate
- Buprofezin
- Cyhalofop-butyl
- Methyl 4-tert-butylbenzoate
- 4-tert-Butylcyclohexyl acetate
- 4-tert-Butylcatechol
- L-GLUTAMIC ACID DI-TERT-BUTYL ESTER HCL
- tert-Butyl methyl ether
- 4-tert-Butylphenol
- tert-Butylbenzene
- Tris(trimethylsilyl)phosphate
- Methyl acrylate
- tert-Butyldimethylsilyl chloride
- tert-Butyl hydroperoxide
- Glutamic acid
- L-Glutamic acid dimethyl ester hydrochloride