Toloxatone Chemical Properties

Melting point:

76°

Boiling point:

358.9±21.0 °C(Predicted)

Density 

1.245±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: >10mg/mL

form 

solid

pka

14.05±0.10(Predicted)

color 

White to off-white

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

RIDADR 

3249

WGK Germany 

3

RTECS 

RQ2867500

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 orally in mice (mg/kg): 1850 (Fauran); also reported as 1500 (Raynaud)

Toloxatone Usage And Synthesis

Description

Toloxatone is a selective, reversible and competitive inhibitor of type A monoamine oxidase (MAO-A) which shows clinical utility as an antidepressant. It is reportedly free of the "cheese effect" in man, possibly due to the reversible nature of its inhibitory effect on intestinal MAO-A in the presence of high concentrations of tyramine.

Originator

Delalande (France)

Uses

Toloxatone is a monoamine oxidase-A (MAO-A) inhibitor.

Definition

ChEBI: 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one is a member of the class of oxazolidinones that is 5-(hydroxymethyl)-1,3-oxazolidin-2-one substituted by a 3-methylphenyl group at position 3. It is a member of toluenes, an oxazolidinone and a primary alcohol.

brand name

HUMORYL

Toloxatone(29218-27-7)Related Product Information

• Duloxetine
• Toloxatone
• HYDROXYPROPYLCARBAMATE
• 2-Oxazolidinone, 5-hydroxymethyl-3-(m-tolyl)-, carbamate
• 3-PHENYL-2-OXAZOLIDINONE