NEOMYCIN B
NEOMYCIN B Basic information
- Product Name:
- NEOMYCIN B
- Synonyms:
-
- Neomycin solution
- neomycine standard solution
- D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1?3)-O-.beta.-D-ribofuranosyl-(1?5)-O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy-
- NEOMYCIN STANDARD
- NEOMYCIN B
- actilin
- actiline
- antibiotique
- CAS:
- 119-04-0
- MF:
- C23H46N6O13
- MW:
- 614.64
- EINECS:
- 204-292-2
- Product Categories:
-
- Mechanism of Action
- N
- L - ZAlphabetic
- NA - NIMore...Close...
- AminoglycosidesAntibiotics
- Antibacterial
- Antibiotics
- Antibiotics A to
- Antibiotics by Application
- Antibiotics N-SAntibiotics
- Antineoplastic and Immunosuppressive AntibioticsAntibiotics
- Chemical Structure Class
- Genetic Marker SelectionAntibiotics
- Interferes with Protein SynthesisSpectrum of Activity
- Mol File:
- 119-04-0.mol
NEOMYCIN B Chemical Properties
- Melting point:
- >194°C (dec.)
- Boiling point:
- 658.4°C (rough estimate)
- Density
- 1.3548 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- solubility
- Aqueous Acid (Slightly), Water (Slightly)
- form
- liquid
- pka
- 12.93±0.70(Predicted)
- color
- clear
- Merck
- 13,6482
- Stability:
- Hygroscopic
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 42/43-63-36/37/38
- Safety Statements
- 26-36/37/39-45-36/37-23
- WGK Germany
- 2
- F
- 8
MSDS
- Language:English Provider:SigmaAldrich
NEOMYCIN B Usage And Synthesis
Uses
Neomycin C is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.
Definition
ChEBI: A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.
General Description
Chemical structure: aminoglycoside
Biochem/physiol Actions
Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L.Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria
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NEOMYCIN B(119-04-0)Related Product Information
- Neomycin sulfate
- NEOMYCIN B
- bacitracin-neomycin-polymyxinointmen
- Neomycin
- Neomycin sulphate soluble powder
- NEOMYCIN E
- ANTI-NEOMYCIN PHOSPHOTRANSFERASE II
- Neomycin B sulfate
- neomycin B sulphate
- NEOMYCIN SULPHATE FOR MICROBIOLOGICAL ASSAY
- NEOMYCIN SULPHATE ORAL
- PENICILLIN STREPTOMYCIN NEOMYCIN "G" IRRADIATED TISSUE CULTURE GRADE
- {NEOMYCIN SULFATE N/H
- PENICILLIN-STREPTOMYCIN-NEOMYCIN GAMMA-&
- Neomycin, hydrochloride
- 100 G NEOMYCIN.SULFATERESEARCH GRADE
- ANTI-NEOMYCIN (INCLUDES BSA CONJUGATE),ANTI-NEOMYCIN
- NEOMYCIN B TRISULFATE SALT SESQUIHYDRATE
- Framycetin