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NEOMYCIN B

Basic information Safety Supplier Related

NEOMYCIN B Basic information

Product Name:
NEOMYCIN B
Synonyms:
  • Neomycin solution
  • neomycine standard solution
  • D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1?3)-O-.beta.-D-ribofuranosyl-(1?5)-O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy-
  • NEOMYCIN STANDARD
  • NEOMYCIN B
  • actilin
  • actiline
  • antibiotique
CAS:
119-04-0
MF:
C23H46N6O13
MW:
614.64
EINECS:
204-292-2
Product Categories:
  • Mechanism of Action
  • N
  • L - ZAlphabetic
  • NA - NIMore...Close...
  • AminoglycosidesAntibiotics
  • Antibacterial
  • Antibiotics
  • Antibiotics A to
  • Antibiotics by Application
  • Antibiotics N-SAntibiotics
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Chemical Structure Class
  • Genetic Marker SelectionAntibiotics
  • Interferes with Protein SynthesisSpectrum of Activity
Mol File:
119-04-0.mol
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NEOMYCIN B Chemical Properties

Melting point:
>194°C (dec.)
Boiling point:
658.4°C (rough estimate)
Density 
1.3548 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
Aqueous Acid (Slightly), Water (Slightly)
form 
liquid
pka
12.93±0.70(Predicted)
color 
clear
Merck 
13,6482
Stability:
Hygroscopic
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Safety Information

Hazard Codes 
Xn
Risk Statements 
42/43-63-36/37/38
Safety Statements 
26-36/37/39-45-36/37-23
WGK Germany 
2
8

MSDS

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NEOMYCIN B Usage And Synthesis

Uses

Neomycin C is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.

Definition

ChEBI: A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.

General Description

Chemical structure: aminoglycoside

Biochem/physiol Actions

Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L.Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria

NEOMYCIN B Preparation Products And Raw materials

Preparation Products

NEOMYCIN BSupplier

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