Sulfamonomethoxine Chemical Properties

Melting point:

203-2060C

Boiling point:

513℃

Density 

1.3936 (rough estimate)

refractive index 

1.6200 (estimate)

Flash point:

>110°(230°F)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

methanol: soluble10mg/mL

pka

pKa 5.94 (Uncertain)

form 

powder

color 

white to white with yellow cast

Water Solubility 

Soluble in water at 10mg/ml with warming. Also soluble in ethanol or methanol

BRN 

621128

Major Application

clinical testing

InChI

InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)

InChIKey

WMPXPUYPYQKQCX-UHFFFAOYSA-N

SMILES

C1(S(NC2C=C(OC)N=CN=2)(=O)=O)=CC=C(N)C=C1

CAS DataBase Reference

1220-83-3(CAS DataBase Reference)

EPA Substance Registry System

Sulfamonomethoxine (1220-83-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

26-36

WGK Germany 

2

RTECS 

WP0550000

HazardClass 

IRRITANT

HS Code 

29350090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3

Toxicity

LD50 oral in rabbit: > 10gm/kg

MSDS

• Language:English Provider:SigmaAldrich

Sulfamonomethoxine Usage And Synthesis

Chemical Properties

White To Off-White Crystalline Powder

Uses

antibacterial

Uses

Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia.

Definition

ChEBI: Sulfamonomethoxine is a sulfonamide and a member of benzenes.

Synthesis Reference(s)

The Journal of Organic Chemistry, 26, p. 2764, 1961 DOI: 10.1021/jo01066a034

General Description

Chemical structure: sulfonamide

Biochem/physiol Actions

Sulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid.

Synthesis

Sodium sulfamethoxazole is commonly used in clinical practice, and the preparation method of sodium sulfamethoxazole includes the following steps:
(1) Add sulfamethoxazole and sodium hydroxide into organic solvent, and stir the reaction for 0.5-2 hours under the temperature condition of 54-98?? to get solution A;
(2) add activated carbon to solution A, stir to decolorize for 0.3-0.8 hours, filter while hot, get filtrate;
(3) The filtrate was first naturally cooled to 20-30 ??, and then at 0-5 ??, holding temperature for 1-3 hours, filtration, to get the filtrate residue;
(4) Wash the filtrate with a small amount of anhydrous ethanol, and dry in vacuum at 55~60 ?? for 2-4 hours, to get sodium sulfamethoxymethane.

Sulfamonomethoxine(1220-83-3)Related Product Information

• Aniline
• Sulfadimethoxine sodium salt
• Sulfameter
• Sulfadiazine
• Sulfadimethoxine
• Sulfanilamide
• Sulfanilic acid
• Sulfasalazine
• Vinyltrimethoxysilane
• ALTRENOGEST
• 4-Aminobenzoic acid
• Glycine
• 6-Aminocaproic acid
• (Trifluoromethoxy)benzene
• 4-Amino-benzenesulfonic acid monosodium salt
• Tris(hydroxymethyl)aminomethane
• 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
• Sulfamonomethoxine sodium