ChemicalBook > Product Catalog > Biochemical Engineering > Condensing agent > 1-Hydroxybenzotriazole hydrate
1-Hydroxybenzotriazole hydrate
1-Hydroxybenzotriazole hydrate Basic information
- Product Name:
- 1-Hydroxybenzotriazole hydrate
- Synonyms:
-
- HOBTM
- HOBT HYDRATE
- HOBT H2O
- 1H-1,2,3-benzotriazol-1-ol hydrate solution
- 1-HYDROXYBENZOTRIAZOLE 15 WT. % SOLUTI&
- 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate
- 1H-benzo[d][1,2,3]triazol-1-ol hydrate
- HOBT.H2O1-Hydroxybenzotriazole hydrate
- CAS:
- 123333-53-9
- MF:
- C6H7N3O2
- MW:
- 153.14
- EINECS:
- 602-929-2
- Product Categories:
-
- Heterocyclic Compounds
- Peptide
- Bases & Related Reagents
- Nucleotides
- Heterocycles
- FINE Chemical & INTERMEDIATES
- 123333-53-9
- Mol File:
- 123333-53-9.mol
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1-Hydroxybenzotriazole hydrate Chemical Properties
- Melting point:
- 155-158 °C(lit.)
- Boiling point:
- 248.8°C (rough estimate)
- Density
- 1.065 g/cm
- refractive index
- 1.6910 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMF: 100 mg/mL, clear
- form
- Solid
- color
- White to Off-White
- Water Solubility
- slightly soluble
- BRN
- 4515
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
- InChIKey
- PJUPKRYGDFTMTM-UHFFFAOYSA-N
- SMILES
- ON1N=NC2C=CC=CC1=2.O
- CAS DataBase Reference
- 123333-53-9(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- F
- Risk Statements
- 5-11-R5-R11-44-1
- Safety Statements
- 15-16-35-7/9-33-S7/9-S33-S16-60-37-26
- RIDADR
- UN 3380 4.1/PG 1
- WGK Germany
- -
- F
- 4.10-8
- Hazard Note
- Highly Flammable
- HazardClass
- 4.1
- HS Code
- 29339980
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
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1-Hydroxybenzotriazole hydrate Usage And Synthesis
Chemical Properties
White to off-white powder
Uses
1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
- Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
- Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.
Uses
A common additive for peptide coupling.
Uses
1-Hydroxybenzotriazole hydrate is used as an additive for oligonucleotide couplings and in racemization-free peptide couplings.
General Description
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
reaction suitability
reaction type: Addition Reactions
Toxics Screening Level
The ITSL 1-Hydroxy benzotriazole has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.
1-Hydroxybenzotriazole hydrate Preparation Products And Raw materials
Preparation Products
Raw materials
1-Hydroxybenzotriazole hydrateSupplier
Suzhou Highfine Biotech Co., Ltd Gold
- Tel
- 0512-68311833 13771732418
- chenmengqi@highfine.com
Changzhou Yuxiang Chemical Co., Ltd Gold
- Tel
- 13809076511
- 344679571@qq.com
Beijing Hezhicheng Chemical Products Co., Ltd Gold
- Tel
- 18311365218
- sales@toachem.com
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel
- 021-61259138 18621169109
- market03@meryer.com
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1-Hydroxybenzotriazole hydrate(123333-53-9)Related Product Information
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- 4-Hydroxy-D-(-)-2-phenylglycine
- 2-Hydroxyphenylacetic acid
- Triclosan
- Methylparaben
- 4-Hydroxybenzaldehyde
- 4-Methoxyphenol
- 4'-Hydroxyacetophenone
- 4-Hydroxybenzoic acid
- Chloral hydrate
- 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
- Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
- BIS(HYDROXYBENZOTRIAZOLYL) CARBONATE
- 6-Chloro-1-hydroxibenzotriazol
- (Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate
- 1-HYDROXY-6-(TRIFLUOROMETHYL)BENZOTRIAZOLE
- TBTU
- 1-Hydroxybenzotriazole