FK 888 Chemical Properties

Boiling point:

901.9±65.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: ≥13mg/mL

form 

powder

pka

13.01±0.40(Predicted)

color 

white to tan

optical activity

[α]/D -135 to -145°, c = 1 in methanol

Safety Information

WGK Germany 

3

FK 888 Usage And Synthesis

Uses

FK 888 is a neurokinin NK1 receptor antagonist, which is active both in vivo and in vitro.

Definition

ChEBI: (2S,4R)-4-hydroxy-1-[(1-methyl-3-indolyl)-oxomethyl]-N-[(2S)-1-[methyl-(phenylmethyl)amino]-3-(2-naphthalenyl)-1-oxopropan-2-yl]-2-pyrrolidinecarboxamide is a peptide.

Biological Activity

Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

storage

Store at -20°C

FK 888(138449-07-7)Related Product Information

• 3-(NAPHTHALEN-2-YL)PROPAN-1-AMINE
• 2-NAPHTHALEN-2-YL-ETHYLAMINE
• (1-Methyl-1H-indol-3-yl)-methylamine
• 1H-PYRROLE-3-METHANAMINE, 1-METHYL-
• 1H-Indole-3-carboxamide(9CI)
• FK 888
• 1-Methylindole-3-carboxaldehyde
• Gramine