2,4-Dichloro-5-methylpyridine Chemical Properties

Boiling point:

221.2±35.0 °C(Predicted)

Density 

1.319±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

0.38±0.10(Predicted)

form 

Liquid

color 

Colorless

Water Solubility 

Slightly soluble in water.

InChI

InChI=1S/C6H5Cl2N/c1-4-3-9-6(8)2-5(4)7/h2-3H,1H3

InChIKey

DUPJNQNLAKJWKU-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C(C)C(Cl)=C1

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2933399990

2,4-Dichloro-5-methylpyridine Usage And Synthesis

Chemical Properties

colorless liquid

Uses

2,4-Dichloro-5-methylpyridine is used as pharmaceutical intermediates.

Synthesis

A solution of phosphorus oxychloride in dichloromethane was added to a mixture of 2-chloro-5-methylpyridine 1-oxide and triethylamine in dichloromethane at 0 ℃. After stirring for 2 hours, the mixture is reacted at room temperature for 24 hours. After that, the water was added and the mixture was neutralized with a sodium hydroxide solution. The organic layer was washed with a saturated brine solution and the aqueous layer was extracted with ethyl acetate and washed with a saturated brine solution. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 2,4-Dichloro-5-methylpyridine. The by-product of this reaction is 2,6-dichloro-3-methyl-pyridine.

2,4-Dichloro-5-methylpyridine(56961-78-5)Related Product Information

• 4-Methylpyridine
• Azamethiphos
• 2-Chloro-5-methylpyridine
• 2,6-Lutidine
• Clopyralid
• Dichlorodimethylsilane
• 2,4,6-Collidine
• 2,4-Dichloropyridine
• 2,4-DICHLORO-5-NITROPYRIDINE
• 2,4-Lutidine
• Dichloromethylsilane
• 3,4-Dichloropyridine
• 2-Chloro-5-chloromethylpyridine
• 3,4-Lutidine
• 4,6-DICHLORO-NICOTINAMIDE
• 4,6-Dichloronicotinic acid
• Ethyl 4,6-dichloronicotinate
• 2,6-DICHLORO-3-METHYLPYRIDINE