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Dolutegravir Impurity 8

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Dolutegravir Impurity 8 Basic information

Product Name:
Dolutegravir Impurity 8
Synonyms:
  • 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,6-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-
  • Dolutegravir 2,6-Difluoro Analog (Dolutegravir 4-Desfluoro 6-Fluoro Impurity)
  • 2,6-Di fluoro Dolutegravir
  • 2,6 Difluoro dolutegravir sodium salt
  • 4-Desfluoro-6-fluoro DolutegravirQ: What is 4-Desfluoro-6-fluoro Dolutegravir Q: What is the CAS Number of 4-Desfluoro-6-fluoro Dolutegravir
  • (4R,12aS)-N-(2,6-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  • Dolutegravir 2,6-difluoro Impurity
  • Dolutegravir Impurity 59
CAS:
2244161-72-4
MF:
C20H19F2N3O5
MW:
419.38
Mol File:
2244161-72-4.mol
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Dolutegravir Impurity 8 Chemical Properties

Boiling point:
664.9±55.0 °C(Predicted)
Density 
1.53±0.1 g/cm3(Predicted)
pka
4.50±1.00(Predicted)
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Dolutegravir Impurity 8 Usage And Synthesis

Uses

4-Desfluoro-6-fluoro Dolutegravir is impurity C of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

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