Mal-PEG1-Val-Cit-PAB-PNP Chemical Properties

Boiling point:

1039.5±65.0 °C(Predicted)

Density 

1.366±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DMF

pka

13.24±0.70(Predicted)

form 

Solid

color 

White to off-white

Mal-PEG1-Val-Cit-PAB-PNP Usage And Synthesis

Description

Mal-PEG1-Val-Cit-PAB-PNP is a cleavable peptide linker. The Val-Cit was designed to be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups at pH 6.5 to 7.5. PNP is a good leaving group.

Uses

Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Mal-PEG1-Val-Cit-PAB-PNP(2249935-92-8)Related Product Information

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