(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Chemical Properties

Density 

1.69±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

H2O: soluble2mg/mL (clear solution, warmed)

form 

powder

pka

9.22±0.20(Predicted)

color 

dark red to purple

Water Solubility 

H2O: 2mg/mL (clear solution, warmed)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-50/53

Safety Statements 

60-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Usage And Synthesis

Uses

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Biological Activity

Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

in vivo

IC 50

HSV-1; GSK-3α: 10 nM (IC₅₀); GSK-3β: 10 nM (IC₅₀); CDK5/p35: 2.4 μM (IC₅₀); CDK2/cyclin A: 4.3 μM (IC₅₀); CDK1/cyclin B: 63 μM (IC₅₀)

storage

Store at +4°C