(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Basic information
- Product Name:
- (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
- Synonyms:
-
- (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
- BIO-ACETOXIME
- GSK-3 INHIBITOR X
- (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one
- 6-Bromoindirubin acetoxime
- 6-Bromoindirubin-3′-acetoxime
- GSK3 Inhibitor IX2
- BIO-acetoxime(GSK-3 Inhibitor)
- CAS:
- 667463-85-6
- MF:
- C18H12BrN3O3
- MW:
- 398.21
- EINECS:
- 200-258-5
- Product Categories:
-
- Other enzyme inhibitors and activators
- Mol File:
- 667463-85-6.mol
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(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Chemical Properties
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- H2O: soluble2mg/mL (clear solution, warmed)
- form
- powder
- pka
- 9.22±0.20(Predicted)
- color
- dark red to purple
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(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Usage And Synthesis
Uses
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Biological Activity
Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
storage
Store at +4°C
(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIMESupplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Shanghai T&W Pharmaceutical Co., Ltd.
- Tel
- +86 21 61551611
TargetMol Chemicals Inc.
- Tel
- 021-021-33632979 15002134094
- marketing@targetmol.com