Angiotensin II, 5-L-isoleucine-8-glycine- Chemical Properties

Density 

1.48±0.1 g/cm3(Predicted)

form 

Solid

pka

3.67±0.10(Predicted)

color 

White to off-white

Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Gly

Angiotensin II, 5-L-isoleucine-8-glycine- Usage And Synthesis

Uses

TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].

References

[1] Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77. DOI:10.1124/mol.111.072801
[2] Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24. DOI:10.1074/jbc.M114.548131

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