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PAGOCLONE

Basic information Safety Supplier Related

PAGOCLONE Basic information

Product Name:
PAGOCLONE
Synonyms:
  • 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone
  • RP 59037
  • Ip 456
  • Rp 62955
  • 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-Methyl-2-oxohexyl)isoindolin-1-one
  • (+)-RP-59037; IP-456; RP-62955; CI-1043
  • CI-1043
  • AGOCLONE
CAS:
133737-32-3
MF:
C23H22ClN3O2
MW:
407.89
EINECS:
225-799-5
Mol File:
133737-32-3.mol
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PAGOCLONE Chemical Properties

Boiling point:
582.1±50.0 °C(Predicted)
Density 
1.273±0.06 g/cm3(Predicted)
pka
1.62±0.30(Predicted)
InChI
InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3
InChIKey
HIUPRQPBWVEQJJ-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1=CC=C2C(=N1)N=C(Cl)C=C2
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PAGOCLONE Usage And Synthesis

Description

Pagoclone is a drug that belongs to the class of cyclopyrrolones. It binds to the benzodiazepine binding site on GABAA receptors and acts as a negative allosteric modulator, thereby enhancing the inhibitory effects of GABA and reducing neuronal excitability.

Uses

Anti-anxiety agent.

Application

Pagoclone has been shown to have anti-inflammatory properties in an animal model of inflammatory bowel disease and may be useful for the treatment of this condition.

brand name

Bextra (Interneuron).

PAGOCLONESupplier

Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Email
xg01_gj@163.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
parabiochem
Tel
025-83453382-8005
Email
sale@parabiochem.com
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
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