PAGOCLONE Chemical Properties

Boiling point:

582.1±50.0 °C(Predicted)

Density 

1.273±0.06 g/cm3(Predicted)

pka

1.62±0.30(Predicted)

form 

Solid

color 

White to off-white

InChI

InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3

InChIKey

HIUPRQPBWVEQJJ-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1=CC=C2C(=N1)N=C(Cl)C=C2

PAGOCLONE Usage And Synthesis

Description

Pagoclone is a drug that belongs to the class of cyclopyrrolones. It binds to the benzodiazepine binding site on GABAA receptors and acts as a negative allosteric modulator, thereby enhancing the inhibitory effects of GABA and reducing neuronal excitability.

Uses

Anti-anxiety agent.

Application

Pagoclone has been shown to have anti-inflammatory properties in an animal model of inflammatory bowel disease and may be useful for the treatment of this condition.

brand name

Bextra (Interneuron).

PAGOCLONE(133737-32-3)Related Product Information

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