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PLECONARIL

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PLECONARIL Basic information

Product Name:
PLECONARIL
Synonyms:
  • PLECONARIL
  • WIN 63843
  • 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
  • Picovir
  • 3-[3,5-DiMethyl-4-[3-(3-Methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoroMethyl)-
  • 1,2,4-Oxadiazole,3-[3,5-diMethyl-4-[3-(3-Methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoroMethyl)-
  • VP 63843
  • 3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
CAS:
153168-05-9
MF:
C18H18F3N3O3
MW:
381.35
Product Categories:
  • Anti-virals
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API
Mol File:
153168-05-9.mol
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PLECONARIL Chemical Properties

Melting point:
61-62°
Boiling point:
481.2±55.0 °C(Predicted)
Density 
1.271
storage temp. 
room temp
solubility 
DMSO: ≥10mg/mL (warmed)
pka
-1.33±0.10(Predicted)
form 
powder
color 
white to beige
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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PLECONARIL Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.

Uses

Picornavirus replication inhibitor. Antiviral.

General Description

Pleconaril is a drug, that has antiviral activity.

Pharmaceutical Applications

An oxadiazole active against most enteroviruses and rhinoviruses. It binds to the hydrophobic pocket of the virus capsid protein VP1, inducing conformational changes that lead to altered receptor binding and viral uncoating. Concerns over safety and efficacy have constrained development of the drug.

Biochem/physiol Actions

Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.

PLECONARILSupplier

J & K SCIENTIFIC LTD.
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LGM Pharma
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MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
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