PLECONARIL
PLECONARIL Basic information
- Product Name:
- PLECONARIL
- Synonyms:
-
- PLECONARIL
- WIN 63843
- 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
- Picovir
- 3-[3,5-DiMethyl-4-[3-(3-Methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoroMethyl)-
- 1,2,4-Oxadiazole,3-[3,5-diMethyl-4-[3-(3-Methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoroMethyl)-
- VP 63843
- 3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
- CAS:
- 153168-05-9
- MF:
- C18H18F3N3O3
- MW:
- 381.35
- Product Categories:
-
- Anti-virals
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
- Mol File:
- 153168-05-9.mol
PLECONARIL Chemical Properties
- Melting point:
- 61-62°
- Boiling point:
- 481.2±55.0 °C(Predicted)
- Density
- 1.271
- storage temp.
- room temp
- solubility
- DMSO: ≥10mg/mL (warmed)
- pka
- -1.33±0.10(Predicted)
- form
- powder
- color
- white to beige
PLECONARIL Usage And Synthesis
Chemical Properties
Off-White Solid
Uses
Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.
Uses
Picornavirus replication inhibitor. Antiviral.
General Description
Pleconaril is a drug, that has antiviral activity.
Pharmaceutical Applications
An oxadiazole active against most enteroviruses and rhinoviruses. It binds to the hydrophobic pocket of the virus capsid protein VP1, inducing conformational changes that lead to altered receptor binding and viral uncoating. Concerns over safety and efficacy have constrained development of the drug.
Biochem/physiol Actions
Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.
PLECONARILSupplier
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