METHYL 4-AMINO-2-FLUOROBENZOATE Chemical Properties

Melting point:

Too Dark to Visualize

Boiling point:

302.3±27.0 °C(Predicted)

Density 

1.264±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

1.45±0.10(Predicted)

form 

Solid

color 

Orange to Brown

Safety Information

HS Code 

2916399090

METHYL 4-AMINO-2-FLUOROBENZOATE Usage And Synthesis

Uses

Methyl 4-amino-2-fluorobenzoate is mainly used as an intermediate in organic synthesis, especially in the field of pharmaceutical manufacturing.

Synthesis

Step 2: Methyl 2-fluoro-4-nitrobenzoate (1.05 g, 5.273 mmol) was dissolved in methanol (MeOH). Palladium/carbon (Pd/C, 105 mg) was added to the resulting solution. The reaction mixture was stirred for 2 hours at room temperature in a hydrogen (H2) atmosphere. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography to give the final pure methyl 4-amino-2-fluorobenzoate (870 mg, 98% yield).

References

[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 19, p. 7042 - 7051
[2] Patent: WO2013/68467, 2013, A1. Location in patent: Page/Page column 57; 59; 60; 61
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 2, p. 337 - 343
[4] Patent: WO2004/14900, 2004, A1. Location in patent: Page 52
[5] Journal of Organic Chemistry, 1990, vol. 55, # 7, p. 2034 - 2044

METHYL 4-AMINO-2-FLUOROBENZOATE(73792-08-2)Related Product Information

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• 4-BROMO-2-FLUOROBENZAMIDE
• 4-amino-2-fluoro-N-methylbenzamide
• 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-
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• 2-FLUORO-N-METHYL-4-NITROBENZAMIDE
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• 4-NITRO-2-(TRIFLUOROMETHYL)BENZONITRILE
• 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
• 4-AMINO-2-FLUOROBENZOIC ACID
• Enzalutamide Impurity 1
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