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(R)-alpha,alpha-Diphenylmethylprolinol

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(R)-alpha,alpha-Diphenylmethylprolinol Basic information

Product Name:
(R)-alpha,alpha-Diphenylmethylprolinol
Synonyms:
  • (2R)-(-)-2-[Diphenyl(hydroxy)methyl]-1-methylpyrrolidine, (-)-alpha,alpha-Diphenyl-N-methyl-D-prolinol
  • (2R)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol
  • (2R)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol,99%e.e.
  • (2R)-(-)-N-Methyl-α,α-diphenyl-2-pyrrolidinemethanol, min. 98%
  • [(2R)-1-methylpyrrolidin-2-yl]-diphenylmethanol
  • (2R)-(-)-N-Methyl-α
  • -diphenyl-2-pyrrolidinemethanol, min. 98%
  • α,α-Diphenyl-N-methyl-D-prolinol, 98%, ee: 98%
CAS:
144119-12-0
MF:
C18H21NO
MW:
267.37
EINECS:
635-081-7
Product Categories:
  • Asymmetric Synthesis
  • Synthetic Organic Chemistry
Mol File:
144119-12-0.mol
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(R)-alpha,alpha-Diphenylmethylprolinol Chemical Properties

Melting point:
68-71 °C
alpha 
-52° (c=1, CHCl3)
Boiling point:
406.8±25.0 °C(Predicted)
Density 
1.116±0.06 g/cm3(Predicted)
refractive index 
-55 ° (C=1, CHCl3)
storage temp. 
Sealed in dry,Room Temperature
form 
Powder
pka
13.15±0.29(Predicted)
color 
white to light-yellow
optical activity
[α]20/D 55.0±4.0°, c = 1% in chloroform stab. with amylenes
BRN 
1535407
CAS DataBase Reference
144119-12-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
10-34
HS Code 
29339900

MSDS

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(R)-alpha,alpha-Diphenylmethylprolinol Usage And Synthesis

Reaction

  1. Chiral amino alcohol assisted asymmetric, enantioselective, aryl transfer of triphenylboroxin to a set of aryl aldehydes in the presence of chiral amino alcohols derived from (S)-proline.
  2. Pyrrolidinylmethanol compound used for the zinc-catalyzed addition of arylboronic acids to aromatic aldehydes, proceeding in high yields and high enantioselectivities (up to 98% ee).

Chemical Properties

white to off-white crystalline powder

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