Tetramethylene sulfoxide Chemical Properties

Boiling point:

235-237 °C(lit.)

Density 

1.158 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.52(lit.)

Flash point:

>230 °F

form 

Liquid

color 

Clear colorless to yellow

Water Solubility 

Fully miscible in water.

BRN 

105274

Dielectric constant

5.6（25℃）

CAS DataBase Reference

1600-44-8(CAS DataBase Reference)

EPA Substance Registry System

Thiophene, tetrahydro-, 1-oxide (1600-44-8)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

XN0830000

TSCA 

T

HS Code 

29041000

Toxicity

mouse,LD50,intraperitoneal,3500mg/kg (3500mg/kg),International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. Vol. 3, Pg. 41, 1961.

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tetramethylene sulfoxide Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

In a comparative study of aromatic fluorodenitration with Potassium fluoride, in several dipolar aprotic solvents, a much faster reaction rate was observed with DMSO or tetramethylene sulfoxide than with the more commonly used Sulfolane.

Definition

ChEBI: Tetrahydrothiophene 1-oxide is a member of tetrahydrothiophenes.

Synthesis Reference(s)

Journal of the American Chemical Society, 63, p. 2939, 1941 DOI: 10.1021/ja01856a021
The Journal of Organic Chemistry, 50, p. 1787, 1985 DOI: 10.1021/jo00210a055
Synthetic Communications, 24, p. 2393, 1994 DOI: 10.1080/00397919408010545

Purification Methods

Shake the oxide with BaO for 4 days, then distil it from CaH2 under reduced pressure. [Beilstein 17 III/IV 36, 17/1 V 38.]

Tetramethylene sulfoxide(1600-44-8)Related Product Information

• Tetramethylguanidine
• Tetramethylpyrazine
• Tetramethylbenzidine
• TETRAHYDRO-THIOPHEN-3-OL
• 4-BUTYROTHIOLACTONE
• Sulfolane
• Tetramethylene sulfoxide
• 3-METHYLSULFOLANE
• 2,4-DIMETHYLSULFOLANE
• SULFOXIDE
• Tetrahydrothiophene
• 3-BROMO-4-HYDROXYSULFOLANE
• 1,1-DIOXIDOTETRAHYDROTHIEN-3-YLAMINE
• 3-METHYLAMINO-N-NITROSOSULFOLANE
• 2,3-DIBROMOSULFOLANE
• (1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)ACETIC ACID
• 3,4-DIBROMOSULFOLANE
• 3-CHLORO-4-HYDROXYTETRAHYDROTHIOPHENE-1,1-DIOXIDE