2-Chloro-5-nitropyridine Chemical Properties

Melting point:

105-108 °C (lit.)

Boiling point:

256.6±20.0 °C(Predicted)

Density 

1.6616 (rough estimate)

refractive index 

1.5500 (estimate)

Flash point:

158°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

-4.22±0.10(Predicted)

form 

Crystalline Powder

color 

Light yellow to beige

Water Solubility 

Solubility in hot methanol. Insoluble in water.

BRN 

120453

InChI

InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H

InChIKey

BAZVFQBTJPBRTJ-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C([N+]([O-])=O)C=C1

CAS DataBase Reference

4548-45-2(CAS DataBase Reference)

NIST Chemistry Reference

2-Chloro-5-nitropyridine(4548-45-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

US7175000

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:2-Chloro-5-nitropyridine

2-Chloro-5-nitropyridine Usage And Synthesis

Chemical Properties

white to light yellow crystal

Uses

2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.

Uses

2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.

Synthesis

Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.

Purification Methods

It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]

2-Chloro-5-nitropyridine(4548-45-2)Related Product Information

• 6-Chloro-2-methyl-3-nitropyridine
• 2-Chloro-3-cyanopyridine
• 2-Chloro-5-chloromethylpyridine
• Pentachloropyridine
• Clopidol
• 1-Chloro-3-nitrobenzene
• 2-Chloro-5-methylpyridine
• 5-Amino-2-chloropyridine
• 2-chloro-5-cyanopyridine
• 2-Chloro-5-fluoropyridine
• 3-Bromo-6-chloro-2-methylpyridine
• 5-Bromo-2-chloropyridine
• 2-Chloro-5-hydroxypyridine
• 2-CHLORO-5-METHOXYPYRIDINE
• 2-Chloro-5-iodopyridine
• 5-Bromo-2-chlorobenzoic acid
• 2,4-DICHLORO-5-NITROPYRIDINE
• Difluorochloromethane