5-Bromopyrimidine Chemical Properties

Melting point:

67-73 °C (lit.)

Boiling point:

168°C(lit.)

Density 

1.6448 (rough estimate)

refractive index 

1.5260 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in chloroform.

form 

Crystalline Powder or Chunks

pka

1.40±0.10(Predicted)

color 

Yellow to beige-brown

BRN 

107326

CAS DataBase Reference

4595-59-9(CAS DataBase Reference)

NIST Chemistry Reference

Pyrimidine, 5-bromo-(4595-59-9)

EPA Substance Registry System

Pyrimidine, 5-bromo- (4595-59-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36/38

Safety Statements 

26-36-37/39

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

T

HazardClass 

IRRITANT, KEEP COLD

HS Code 

29335990

MSDS

• Language:English Provider:5-Bromopyrimidine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Bromopyrimidine Usage And Synthesis

Chemical Properties

yellow solid crystalline, insoluble in water, soluble in organic solvents such as benzene and toluene.

Uses

5-Bromopyrimidine was used in the synthesis of N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction, (5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol.

Uses

5-Bromopyrimidine was used in the synthesis of:
N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction
(5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol
Intermediate for the synthesis of plant growth regulator flurprimidol

Application

5-Bromopyrimidine is a compound useful in organic synthesis.

Preparation

5-Bromopyrimidine is prepared by reacting dibromodifuranone with formamide in the presence of B2O2 catalyst at 180-185°C to obtain the product.

General Description

Rapid nucleophilic displacement reactions of 5-bromopyrimidine with nucleophiles under microwave irradiation has been studied. 5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine.

5-Bromopyrimidine(4595-59-9)Related Product Information

• 5-Bromo-2,4-dichloropyrimidine
• Fluorocytosine
• Alloxan
• Pyrimethamine
• Cytosine
• Silver sulfadiazine
• Sulfadiazine
• Pyrimidine
• Uracil
• 5-Bromophthalide
• 5-Bromonicotinic acid
• 5-Bromoindole
• 2-AMINO-5-BROMOPYRIMIDINE,2-Amino-5-bromopyrimidine ,98%
• 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE
• 5-Bromo-4,6-dichloropyrimidine
• 2-Amino-5-bromo-4,6-dimethylpyrimidine
• 5-Bromo-4,6-dihydroxypyrimidine
• 5-BROMO-2,4-DIMETHOXYPYRIMIDINE