N-Methyl-D-aspartic acid Chemical Properties

Melting point:

187-192 °C

alpha 

-28 º (c=1, HCl 6N)

Boiling point:

267.21°C (rough estimate)

Density 

1.4285 (rough estimate)

refractive index 

-15 ° (C=2, H2O)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly)

pka

2.21±0.23(Predicted)

form 

solid

color 

white

Water Solubility 

slightly soluble

Sensitive 

Hygroscopic

Merck 

14,6662

BRN 

1724431

LogP

1.390 (est)

CAS DataBase Reference

6384-92-5(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

CI9457000

F 

10

HS Code 

29225090

MSDS

• Language:English Provider:(R)-2-(Methylamino)succinic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

N-Methyl-D-aspartic acid Usage And Synthesis

Chemical Properties

white to off-white crystalline powder

Uses

NMDA agonist

Uses

NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

Definition

ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration.

General Description

N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.

Biological Activity

Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.

storage

Room temperature

References

[1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.
[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7.

N-Methyl-D-aspartic acid(6384-92-5)Related Product Information

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