Coenzyme A
Coenzyme A Basic information
- Product Name:
- Coenzyme A
- Synonyms:
-
- [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
- CONENZYME A
- Coenzyme a, free acid
- Coenzyme A, free acid, lyophilized, min. 75% (enzym.)
- COENZYME A FREE ACID FROM YEAST
- Coenzyme A, free acid, lyophilized, 75%
- Coenzyme A / Q0 / Q10
- COENZYM A FREE ACID
- CAS:
- 85-61-0
- MF:
- C21H36N7O16P3S
- MW:
- 767.53
- EINECS:
- 201-619-0
- Product Categories:
-
- Vitamin series
- 85-61-0
- Mol File:
- 85-61-0.mol
Coenzyme A Chemical Properties
- Density
- 1.96±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- pka
- 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
- color
- White to light yellow
- Merck
- 13,2491
- BRN
- 77809
- InChI
- InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1
- InChIKey
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N
- SMILES
- SCCNC(=O)CCNC(=O)[C@@H](C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C)O
- LogP
- -4.358 (est)
- EPA Substance Registry System
- Coenzyme A (85-61-0)
MSDS
- Language:English Provider:CoA
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
Coenzyme A Usage And Synthesis
Description
Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-
Chemical Properties
yellowish lyophilisate
Uses
A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.
Uses
Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.
Definition
ChEBI: Coenzyme A is a thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit. It has a role as an Escherichia coli metabolite, a mouse metabolite and a coenzyme. It is functionally related to an ADP. It is a conjugate acid of a coenzyme A(4-).
General Description
Coenzyme A (CoA) is a cofactor with a molecular weight of 797 Da. Its biological structure is formed from pantothenic acid (vitamin B5), cysteine and adenosine triphosphate through an evolutionarily conserved pathway. CoA is primarily involved in cellular oxidative pathways, including fatty acid beta-oxidation, carbohydrate, amino acid oxidation, and the Krebs cycle; as well as in lipid synthesis, protein modification, and membrane transport. CoA serves as a carrier for the activation of acyl groups, which can be transferred to amides, esters, or acid anhydrides. CoA can also be regulate a variety of metabolic processes at different levels as substrates, allosteric regulators, and through post-translational modifications of histones and other non-histone proteins. It is an essential cofactor in all organisms.
Biochem/physiol Actions
Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes.
Purification Methods
The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]
Coenzyme A Preparation Products And Raw materials
Raw materials
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Coenzyme A(85-61-0)Related Product Information
- Coenzyme Q10
- SUCCINYL COENZYME A SODIUM SALT
- COENZYME
- COENZYME A TRILITHIUM SALT
- ACETYL COENZYME A (C2:0) LITHIUM
- Acetyl coenzyme A sodium salt
- Cocarboxylase
- D-Biotin
- NADH, disodium salt
- NAD+
- COENZYME Q9
- LAUROYL COENZYME A C12:0 LITHIUM SALT,N-DODECANOYL COENZYME A LITHIUM SALT
- NADP, Disodium Salt
- Nadph tetrasodium salt
- MALONYL COENZYME A TETRALITHIUM SALT
- 2,3-Dimethoxy-5-methyl-p-benzoquinone
- COENZYME A SODIUM SALT
- N-DECANOYL COENZYME A (C10:0)