3,4-Dichloronitrobenzene Chemical Properties

Melting point:

39-41 °C(lit.)

Boiling point:

255-256 °C(lit.)

Density 

1.48 g/cm3 (55℃)

vapor pressure 

0.01 hPa (20 °C)

refractive index 

1.5929 (estimate)

Flash point:

255 °F

storage temp. 

Store below +30°C.

solubility 

0.151g/l

form 

Crystalline Mass

color 

Yellow to brown

Water Solubility 

151 mg/L (20 ºC)

FreezingPoint 

30~31℃

BRN 

1818163

Stability:

Stable. Incompatible with strong oxidizing agents, strong bases.

CAS DataBase Reference

99-54-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,2-dichloro-4-nitro-(99-54-7)

EPA Substance Registry System

3,4-Dichloronitrobenzene (99-54-7)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-36-43-51/53

Safety Statements 

26-36/37-61-39-24/25

RIDADR 

2811

WGK Germany 

3

RTECS 

CZ5250000

Autoignition Temperature

420 °C

TSCA 

Yes

HazardClass 

9

PackingGroup 

III

HS Code 

29049085

Hazardous Substances Data

99-54-7(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 643 mg/kg LD50 dermal Rat > 2000 mg/kg

MSDS

• Language:English Provider:3,4-DCNB
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3,4-Dichloronitrobenzene Usage And Synthesis

Chemical Properties

colourless to yellow crystals or beige powder

Uses

1,2-Dichloro-4-nitrobenzene is an intermediate in the synthesis of agrochemicals. Studies have been conducted to use 1,2-Dichloro-4-nitrobenzene as an organic intermediate for the synthetic preparation of ciprofloxacin (C482500).

Production Methods

Nitration of 1,2-dichlorobenzene with mixed acid at 35 – 60 ℃ results in a mixture of 3-nitro (10 %) and 4-nitro (90 %) isomers, which are separated by crystallization. A more expensive process (two stages from chlorobenzene) is based on chlorination of molten 4-chloronitrobenzene (90 – 100 ℃) by a process similar to that used for 3- chloronitrobenzene production. Chlorination has the advantage of giving a pure product, but it cannot be used if the isomeric 1,2-dichloro-3-nitrobenzene is also required.

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 3494, 1977 DOI: 10.1021/jo00442a009

General Description

Colorless crystals or light beige solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Can react vigorously with oxidizing materials.

Fire Hazard

3,4-Dichloronitrobenzene is combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from absolute EtOH. [Beilstein 5 IV 726.]

3,4-Dichloronitrobenzene(99-54-7)Related Product Information

• Sodium 3-nitrobenzenesulphonate
• 4-Nitrobenzoic acid
• 3,4-Difluoronitrobenzene
• 1,2-Dichloro-4-(chloromethyl)benzene
• 2,4-DICHLORONITROBENZENE PESTANAL, 250 M,2,4-DICHLORONITROBENZENE
• 1,3,5-trichloro-2,4-dinitrobenzene
• 2,3,4,5-Tetrachloronitrobenzene
• 1,2-DICHLORO-4-FLUORO-5-NITROBENZENE
• 3,4-Dichloronitrobenzene
• N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE
• 2,3,4-TRICHLORONITROBENZENE
• Nitrobenzene
• 2,5-Dichloronitrobenzene
• 1,3-Dinitrobenzene
• 2,3-DICHLORONITROBENZENE,2,3-DICHLORONITROBENZENE PESTANAL, 250 M,2,3-DICHLORONITROBENZENE 99%
• 1,2,3,4-TETRACHLORO-5,6-DINITROBENZENE
• 1,2-DICHLORO-4,5-DINITRO-BENZENE
• Quintozine