Squalene Chemical Properties

Melting point:

−75 °C(lit.)

Boiling point:

285 °C25 mm Hg(lit.)

Density 

0.858 g/mL at 25 °C(lit.)

vapor pressure 

0Pa at 25℃

refractive index 

n20/D 1.494(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

DMSO : 16.67 mg/mL (40.59 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

form 

liquid

color 

light yellow

Odor

oil, faint odor

Water Solubility 

<0.1 g/100 mL at 19 ºC

Merck 

14,8768

BRN 

1728919

LogP

14.12 at 24℃

CAS DataBase Reference

111-02-4(CAS DataBase Reference)

NIST Chemistry Reference

2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (all-E)-(111-02-4)

EPA Substance Registry System

Squalene (111-02-4)

Safety Information

Safety Statements 

24/25

WGK Germany 

2

RTECS 

XB6010000

F 

8-10-23

TSCA 

Yes

HS Code 

29012980

Hazardous Substances Data

111-02-4(Hazardous Substances Data)

Toxicity

mouse,LD50,intravenous,1800mg/kg (1800mg/kg),Japanese Journal of Cancer Research. Vol. 76, Pg. 1021, 1985.

MSDS

• Language:English Provider:(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Squalene Usage And Synthesis

Chemical Properties

clear colourless to faint yellow oil

Uses

Squalene is a natural triterpene that plays an important role in the synthesis of cholesterol, steroid hormones, and vitamin D in the human body. Squalene is commonly used as a biochemical precursor i n the preparation of steroids. Squalene is also a natural moisturizer with low acute toxicity and is not significant human skin irritants or sensitizers.

Uses

cosmetic and pharmaceutical excipient

Uses

Bactericide; intermediate in manufacture of pharmaceuticals, organic coloring materials, rubber chemicals, aromatics and surface active agents.

Production Methods

Squalene is extracted from shark liver or synthesized from hexaphenyl-1,4-butanediyldiphosphonium dibromide and 6,10-dimethyl-5,9-undecadien-2-one (geranylacetone, industrial intermediate in the vitamin E synthesis).

Definition

ChEBI: A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration.

General Description

Clear, slightly yellow liquid with a faint odor. Density 0.858 g / cm3.

Air & Water Reactions

May become discolored on exposure to air. Insoluble in water.

Reactivity Profile

(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene is incompatible with strong oxidizing agents. .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition (all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene emits toxic fumes of carbon monoxide and carbon dioxide.

Fire Hazard

(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene is probably combustible.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Squalene is a biosynthetic precursor to all steroids. It acts as a cytoprotective agent to normal cells exposed to carcinogens and antitumor agents. Squalene helps in equalizing the blood cholesterol levels. It increases the production of HDL (high density lipoprotein) and the excretion of LDL (low density lipoprotein). This helps in reducing the risk of heart disease and protects the less stable body fats from oxidation. It is also used in treating hypercholesterolemia. Squalene is known to improve the efficiency of cholesterol lowering drugs. It also serves as an antioxidant by preventing the effects of free radical. It protects skin from drying and other environmental conditions such as oxidation, ultraviolet rays and pollutants. Squalene is known to promote wound healing.

target

COX | STAT | FOXP3 | Nrf2 | SOD | GPx

Squalene(111-02-4)Related Product Information

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