Brodimoprim Chemical Properties

Melting point:

225-228°

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Sparingly)

pka

7.15(at 25℃)

form 

Solid

color 

White to Pale Yellow

Stability:

Light Sensitive

Brodimoprim Usage And Synthesis

Description

Brodimoprim, a dihydrofolate reductase inhibitor, was introduced for the treatment of common infections of upper respiratory tract such as sinusitis and exacerbation of chronic bronchitis. It has a broad spectrum of antimicrobial activities against most Gram-positive and -negative pathogens including some bacterial strains that are resistant to amoxicillin, a widely used antibiotic for the indicated infections. Brodimoprim also has a favorable pharmacokinetic profile exemplified by its long half-life and good tissue penetration.

Chemical Properties

Off-White to Pale Yellow Solid

Originator

Helsinn (Switzerland)

Uses

A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.

Definition

ChEBI: An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group.

brand name

Hyprim;Unitrim

Brodimoprim(56518-41-3)Related Product Information

• Trifluridine
• 4-Dimethylaminobenzoic acid
• 1-beta-D-Arabinofuranosyluracil
• UMP
• N,N-Dimethylbenzylamine
• Doxifluridine
• 4-Dimethylaminobenzaldehyde
• 4-Dimethylaminopyridine
• Allyl bromide
• Dimethyldimethoxysilane
• 2-Dimethylaminoethanol
• 1-BROMO-2,6-DIMETHOXYBENZENE
• Pyrimidine
• 2,4-Diaminopyrimidine
• 4-BROMO-3-METHOXYPHENYL-P-TOLUENESULFONATE
• 5-Benzyl-2,4-diaminopyrimidine
• 2,4-Diamino-5-(3-methoxybenzyl)pyrimidine
• Brodimoprim