GABOXADOL HYDROCHLORIDE
GABOXADOL HYDROCHLORIDE Basic information
- Product Name:
- GABOXADOL HYDROCHLORIDE
- Synonyms:
-
- 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate
- 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride
- THIP HYDROCHLORIDE (GABOXADOL) POST-SYNA PTIC GABA RE
- THIP hydrochloride, 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
- Einecs 285-687-7
- Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, Monohydrochloride
- Gaboxadol hydrochloride solid, >=98% (HPLC)
- 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt)
- CAS:
- 85118-33-8
- MF:
- C6H9ClN2O2
- MW:
- 176.6
- EINECS:
- 285-687-7
- Mol File:
- 85118-33-8.mol
GABOXADOL HYDROCHLORIDE Chemical Properties
- Melting point:
- 236 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- ethanol: soluble0.91mg/mL
- form
- solid
- color
- white
- Merck
- 14,4321
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- NY3396800
- HS Code
- 2934.99.9001
GABOXADOL HYDROCHLORIDE Usage And Synthesis
Uses
GABAergic Agonist
Uses
As a molecular probe to study GABA receptors.
Uses
Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.
Uses
Gaboxadol is a sleep aid drug used for the treatment of chronic pain and insomnia. Gaboxadol is also known to exhibit antidepressant like properties through its agonistic activities towards GABA sites .
General Description
Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.
Biochem/physiol Actions
GABAA receptor agonist.
in vivo
Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by Fmr1 KO2 mice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity in Fmr1 KO2 mice[2].
| Animal Model: | Fmr1?KO2 mice (deletion of the promoter and first exon of?Fmr1?resulting in mRNA and protein null mice)[2] |
| Dosage: | 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Normalized Hyperactivity Observed in?Fmr1?KO2 mice. |
storage
Store at RT
GABOXADOL HYDROCHLORIDESupplier
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