1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Basic information
- Product Name:
- 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt
- Synonyms:
-
- 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt
- Allopurinolsodium
- 1H-Pyrazolo[3,4-d]pyrimidin-4-ol monosodium salt
- Sodium allopurinol
- Allopurinol SodiuM (AlopriM)
- SodiuM 1H-pyrazolo[3,4-d]pyriMidin-4-olate
- Aloprim
- 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, sodium salt (1:1)
- CAS:
- 17795-21-0
- MF:
- C5H5N4NaO
- MW:
- 160.11
- EINECS:
- 241-771-5
- Product Categories:
-
- Inhibitors
- Mol File:
- 17795-21-0.mol
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Chemical Properties
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.31(at 25℃)
- form
- Solid
- color
- White to off-white
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Usage And Synthesis
Uses
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5].
in vivo
Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse[3].
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse[4].
| Animal Model: | 20-30 g, male Swiss Albino mice[3] |
| Dosage: | 39 mg/kg |
| Administration: | P.o.; daily for 21 successive days |
| Result: | Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s. |
| Animal Model: | 30-40 g, male adult Swiss albino mice[4] |
| Dosage: | 10, 50, 100, 200, 400 mg/kg |
| Administration: | I.p. |
| Result: | Produced dose-dependent anti-nociception in the tail-flick, hot-plate. |
References
[1] Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58(1):87-114. DOI:10.1124/pr.58.1.6
[2] Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472. DOI:10.1128/AAC.5.5.469
[3] Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. DOI:10.4103/0253-7613.111922
[4] Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72. DOI:10.1111/j.1476-5381.2008.00025.x
[5] Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649. DOI:10.1371/journal.pone.0123649
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