thenalidine Chemical Properties

Melting point:

95-97°

Boiling point:

bp0.02 158-160°

Density 

1.140±0.06 g/cm3(Predicted)

pka

pKa 3.36±0.06(H2O t undefined I = 0.30 (NaCl)) (Uncertain);8.39±0.07(H2O t undefined I = 0.30 (NaCl)) (Uncertain)

thenalidine Usage And Synthesis

Uses

Thenalidine is an antihistamine that has anticholinergic properties which is used as an antipruritic drugs.

Definition

ChEBI: Thenalidine is a dialkylarylamine and a tertiary amino compound.

brand name

Sanbosten.

World Health Organization (WHO)

Thenalidine, a piperidine antihistamine, was introduced in 1953 for the management of dermatologic and allergic conditions. By 1958 its use had been associated with cases of severe neutropenia, two of them fatal, which led to its withdrawal in the United States of America and subsequently in the United Kingdom. Over the next fifteen years, continued reports of its association with cases of neutropenia resulted in further withdrawals in many countries. It is apparently still available, however, in some combination products.

Synthesis

Thenalidine is synthesized by alkylation of 1-methyl-4-phenylaminopiperidine with 2-chloromethyl thiophene .

thenalidine(86-12-4)Related Product Information

• N-(1-ACETYLPIPERIDIN-4-YL)-N-(2,3-DIHYDRO-1-(METHYLSULPHONYL)-(1H)-INDOL-5-YL)THIOPHENE-2-CARBOXAMIDE
• thenalidine tartrate
• N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-(1-BENZYLPIPERIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE
• N-(1-BENZYLPIPERIDIN-4-YL)-N-(2,3-DIHYDRO-1-(METHYLSULPHONYL)-(1H)-INDOL-5-YL)THIOPHENE-2-CARBOXAMIDE
• N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-6-YL)-N-(1-BENZYLPIPERIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE
• N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-(1-ACETYLPIPERIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE
• N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-5-YL)-N-(1-PROPYLPIPERIDIN-4-YL)-THIOPHENE-2-CARBOXAMIDE
• N-[2-METHYL-1H-INDOL-5-YL]-N-[1-(2-PHENYLETHYL)PIPERIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
• N-(1-ACETYL-2,3-DIHYDRO-(1H)-INDOL-6-YL)-N-(1-METHYLPIPERIDIN-4-YL)THIOPHENE-2-CARBOXAMIDE
• N-(1-ACETYLPIPERIDIN-4-YL)-N-(2-TERT-BUTYL-(1H)-INDOL-5-YL)THIOPHENE-2-CARBOXAMIDE
• thenalidine