4-(dimethylammonio)piperidinium dichloride Chemical Properties

Melting point:

288-290℃

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to yellow Solid

InChI

InChI=1S/C7H16N2.ClH/c1-9(2)7-3-5-8-6-4-7;/h7-8H,3-6H2,1-2H3;1H

InChIKey

IDCJGSDAPFXTGB-UHFFFAOYSA-N

SMILES

N(C1CCNCC1)(C)C.Cl

Safety Information

HazardClass 

IRRITANT

HS Code 

29333990

4-(dimethylammonio)piperidinium dichloride Usage And Synthesis

Chemical Properties

White powder

Uses

Dimethyl-piperidin-4-yl-amine DiHCl

Synthesis

General procedure for the synthesis of 4-dimethylaminopiperidine dihydrochloride from N-Boc-4-dimethylaminopiperidine: 10.0 g of tert-butyl 4-(dimethylamino)piperidine-1-carboxylate (0.044 mol) was dissolved in 60 mL of dichloromethane and cooled in an ice bath. Subsequently, 4 mol/L of HCl/dioxane solution (34.5 mL, 0.138 mol) was slowly added, and stirring was maintained during the dropwise addition. The reaction mixture was continued to be stirred under ice bath conditions for 8 hours. Upon completion of the reaction, a large amount of white solid precipitate was observed to be generated, and the precipitate was collected by filtration and washed with a small amount of cold dichloromethane to remove residual HCl. 6.4 g of the target product, 4-dimethylaminopiperidine dihydrochloride, was finally obtained in 85.3% yield.

References

[1] Patent: CN108456183, 2018, A. Location in patent: Paragraph 0020; 0101-0103
[2] Synthetic Communications, 2009, vol. 39, # 2, p. 273 - 277

4-(dimethylammonio)piperidinium dichloride(4876-59-9)Related Product Information

• 4-(dimethylammonio)piperidinium dichloride
• carpipramine dihydrochloride
• N,N-Dimethylpiperidin-4-amine
• N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
• 4-(1-pyrrolidinyl)piperidine dihydrochloride
• 1-benzyl-4-(dimethylammonio)piperidinium dichloride
• N-(1-ACETYLPIPERIDIN-4-YL)-2,6-DICHLORO-N-(CYCLOPROPYL)PYRIDINE-4-CARBOXAMIDE
• (2,4-DICHLOROPHENYL)[8-(2-PYRIMIDINYL)-1-OXA-4,8-DIAZASPIRO[4.5]DEC-4-YL]METHANONE
• (8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3,3-DIMETHYL-1,4,8-TRIAZASPIRO[4.5]DEC-1-YL)(2,4-DICHLOROPHENYL)METHANONE
• 8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-N-(2,4-DICHLOROPHENYL)-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOXAMIDE
• 3-BENZYL-N-(4-CHLOROPHENYL)-8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOXAMIDE
• Pipamperone
• N-(4-CHLOROPHENYL)-8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOXAMIDE
• 2-CHLORO-1-(2,8-DIMETHYL-1,2,3,4,4A,9B-HEXAHYDRO-5H-PYRIDO[4,3-B]INDOL-5-YL)-1-ETHANONE HYDROCHLORIDE
• [3H]SR 142801
• N-(2-TERT-BUTYL-(1H)-INDOL-5-YL)-2,6-DICHLORO-N-(1-PROPYLPIPERIDIN-4-YL)PYRIDINE-4-CARBOXAMIDE
• N-(1-BENZYLPIPERIDIN-4-YL)-N-(2-TERT-BUTYL-(1H)-INDOL-5-YL)-2,6-DICHLOROPYRIDINE-4-CARBOXAMIDE
• N-[2-((1-ACETYLPIPERIDIN-4-YL)CYCLOPROPYLAMINOACETYLTHIO)ETHYL]-2,6-DICHLOROPYRIDINE-4-CARBOXAMIDE