2,3-Dichloro-6-methoxyquinoxaline Chemical Properties

Density 

1.450

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to pink Solid

InChI

InChI=1S/C9H6Cl2N2O/c1-14-5-2-3-6-7(4-5)13-9(11)8(10)12-6/h2-4H,1H3

InChIKey

NFJQDGNCJJPQNV-UHFFFAOYSA-N

SMILES

N1C2C(=CC(OC)=CC=2)N=C(Cl)C=1Cl

Safety Information

HS Code 

2933998090

2,3-Dichloro-6-methoxyquinoxaline Usage And Synthesis

Uses

2,3-Dichloro-6-methoxyquinoxaline is used for preparation of antibacterial and antifungal activity of (tetrazolo[1,5-a]quinoxalinyl)dihydrophthalazine-diones as reactant or reagent.

Synthesis

General procedure for the synthesis of 2,3-dichloro-6-methoxyquinoxaline from 6-methoxyquinoxaline-2,3-diol: 6-methoxy-1,4-dihydro-quinoxaline-2,3-dione (15.5 g, 1 mmol) was dissolved in 75 mL of phosphorochloride, and the reaction mixture was heated and refluxed for 24 hours. Upon completion of the reaction, a 1:1 mixture of water and methanol was slowly added at 0 to 5 °C to quench the reaction. Subsequently, the resulting precipitate was collected by filtration and dried under reduced pressure to give 17.2 g of 2,3-dichloro-6-methoxyquinoxaline in 93.1% yield.

References

[1] Patent: KR2018/106597, 2018, A. Location in patent: Paragraph 0451-0454
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4508 - 4522
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 8, p. 2240 - 2254

2,3-Dichloro-6-methoxyquinoxaline (39267-04-4)Related Product Information

• 2,3-DIHYDROXY-6-METHOXYQUINOXALINE
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• 7,8-DICHLORO-2,3,4A,10A-TETRAHYDRO[1,4]DIOXINO[2,3-G]QUINOXALINE
• 2,3-Dichloropyrazine
• 6-METHOXYQUINOXALINE
• 2,3-Dichloro-6-methoxyquinoxaline
• 6-Hydroxyquinoxaline
• 2,3-DICHLORO-6,7-DIMETHOXYQUINOXALINE
• 2,3-Dichloroquinoxaline