2-bromo-4-chloropropiophenone Chemical Properties

Melting point:

77-79 °C(Solv: ligroine (8032-32-4))

Boiling point:

296.7±15.0 °C(Predicted)

Density 

1.518±0.06 g/cm3(Predicted)

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

Off-White to Pale Beige

InChI

InChI=1S/C9H8BrClO/c1-6(10)9(12)7-2-4-8(11)5-3-7/h2-6H,1H3

InChIKey

SAKMPXRILWVZEG-UHFFFAOYSA-N

SMILES

C(C1=CC=C(Cl)C=C1)(=O)C(Br)C

Safety Information

HS Code 

2914790090

2-bromo-4-chloropropiophenone Usage And Synthesis

Uses

2-bromo-4-chloropropiophenone can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.

Application

2-bromo-4-chloropropiophenone is an analytical reference standard categorized as a precursor in the synthesis of cathinones, including 4-chlorocathinone, 4-chloro-N, N-dimethylcathinone, 4-chloro-N-isopropylcathinone, 4-chloro-N-butylcathinone, 4-chloroethcathinone, and 4'-chloro-α-pyrrolidinopropiophenone. 2-Bromo-4'-chloropropiophenone is also a precursor in the synthesis of 4-chloromethcathinone.

Synthesis

A solution of 15.9 g (0.1 mol) of bromine in 20 ml of chloroform is added dropwise to a solution of 16.8 g (0.1 mol) of 4'-chloropropiophenone in 100 ml of chloroform, in the presence of a small amount of aluminium chloride, and the mixture is stirred overnight. After filtration and evaporation of the filtrate, the crystalline residue is washed with petroleum ether. When dry, it melts at 75° C.

2-bromo-4-chloropropiophenone (877-37-2)Related Product Information

• 4'-Chloropropiophenone
• 4'-BROMO-3-CHLOROPROPIOPHENONE
• p-Bromo-β-chloropropiophenone
• 2-BROMO-3'-CHLOROPROPIOPHENONE
• 2-bromo-2'-chloropropiophenone
• 4'-BROMO-2-CHLOROPROPIOPHENONE
• 3-BROMO-4-(4-CHLORO-PHENYL)-4-OXO-BUTYRIC ACID
• 2-Bromo-1-(2,4-dichlorophenyl)pentan-1-one
• 2-BROMO-1-(4-CHLOROPHENYL)-2-(4-METHYLPHENYL)ETHAN-1-ONE
• 2-bromo-2-4-dichloropropiophenone
• 2-BROMO-1-(4-CHLOROPHENYL)-2-PHENYLETHAN-1-ONE
• 2-bromo-4-chloropropiophenone
• 2-BROMO-1-(3,4-DICHLORO-PHENYL)-PENTAN-1-ONE
• 2-Bromo-1-(2,4-dichlorophenyl)butan-1-one