ChemicalBook > Product Catalog > Organic Chemistry > Heterocyclic Compounds > (R)-1-N-Boc-2-(hydroxymethyl)piperazine
(R)-1-N-Boc-2-(hydroxymethyl)piperazine
(R)-1-N-Boc-2-(hydroxymethyl)piperazine Basic information
- Product Name:
- (R)-1-N-Boc-2-(hydroxymethyl)piperazine
- Synonyms:
-
- (R)-1-Boc-2-Hydroxymethyl-piperazine
- 1-Piperazinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)-
- tert-butyl (R)-2-(hydroxymethyl)piperazine-1-carboxylate
- (R)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE HCl
- 2-Methyl-2-propanyl(2R)-2-(hydroxymethyl)-1-piperazinecarboxylate
- (R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate
- (R)-1-Boc-2-Hydroxymethyl-piperazine ,98%
- (S)-1-Boc-2-Hydroxymethyl-piperazine ,98%
- CAS:
- 169448-87-7
- MF:
- C10H20N2O3
- MW:
- 216.28
- Product Categories:
-
- Piperaizine
- Mol File:
- 169448-87-7.mol
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(R)-1-N-Boc-2-(hydroxymethyl)piperazine Chemical Properties
- Boiling point:
- 324.0±17.0 °C(Predicted)
- Density
- 1.085±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 14.97±0.10(Predicted)
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(R)-1-N-Boc-2-(hydroxymethyl)piperazine Usage And Synthesis
Uses
(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof.
Synthesis
Lithium aluminum hydride (1M in THF, 26 ml) was added to a solution of L-TERT- butyl 2-methyl (2R)-piperazine-1, 2-dicarboxylate (2. 55 g) in THF (70 ml) at-40°C, and then the reaction was warmed to room temperature. After stirring for 1 h, this reaction system was cooled to 0°C and quenched by sequential addition of water (1 ml), sodium hydroxide (2N, 1 ml), and then water (2 ml). The resulting slurry was filtered and concentrated in vacuo to give (R)-1-N-Boc-2-(hydroxymethyl)piperazine.
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(R)-1-N-Boc-2-(hydroxymethyl)piperazine(169448-87-7)Related Product Information
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