6-CHLORO-PYRIDINE-2-CARBONYL CHLORIDE Chemical Properties

Boiling point:

239.0±20.0 °C(Predicted)

Density 

1.454±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-2.22±0.10(Predicted)

Safety Information

HS Code 

2933399990

6-CHLORO-PYRIDINE-2-CARBONYL CHLORIDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 6-chloropyridinecarbonyl chloride from 6-hydroxypyridine-2-carboxylic acid: to 20 g (144 mmol) of 6-hydroxypyridine-2-carboxylic acid was added 50.6 g (330 mmol) of phosphorus trichloride and 99.8 g (479 mmol) of phosphorus pentachloride, and the reaction was carried out by stirring the mixture for 8 hours at 90 °C. Upon completion of the reaction, the mixture was cooled, followed by the addition of 8.6 g of formic acid, and the reaction mixture was concentrated using a rotary evaporator to quantitatively obtain the target product 6-chloropyridinecarbonyl chloride.

References

[1] Patent: US2004/14977, 2004, A1. Location in patent: Page 20
[2] Patent: EP1302466, 2003, A1

6-CHLORO-PYRIDINE-2-CARBONYL CHLORIDE(80099-98-5)Related Product Information

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