TAPSO Chemical Properties

Melting point:

224-229 °C (dec.)

Density 

1.07607 g/cm3(Temp: 25.00 °C)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

H₂O: 1 M at 20 °C, clear, colorless

form 

Powder

color 

Off-white to yellow

pka

7.6(at 25℃)

PH Range

7.0 - 8.2

Water Solubility 

soluble

Merck 

13,9148

BRN 

2113949

InChI

InChI=1S/C7H17NO7S/c9-3-7(4-10,5-11)8-1-6(12)2-16(13,14)15/h6,8-12H,1-5H2,(H,13,14,15)

InChIKey

RZQXOGQSPBYUKH-UHFFFAOYSA-N

SMILES

C(S(O)(=O)=O)C(O)CNC(CO)(CO)CO

CAS DataBase Reference

68399-81-5(CAS DataBase Reference)

EPA Substance Registry System

1-Propanesulfonic acid, 2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]- (68399-81-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29221990

MSDS

• Language:English Provider:2-Hydroxy-N-(tris(hydroxymethyl)methyl)-3-aminopropanesulfonic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

TAPSO Usage And Synthesis

Chemical Properties

white powder

Uses

TAPSO is a zwitterionic biological buffer often used as a buffering agent in biological and biochemical research. It has a pKa value of 7.635 (I=0, 25°C) and can be used to make buffer solutions in the pH range 7.0-8.2. As an Good'buffer, TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides[1]. TAPSO can serve as good stabilizers for the globular protein BSA, in the aqueous solutions[2].The solubilities of TAPSO increase with increasing concentration of the salts (salting-in effect)[3].

References

[1] Gupta B, et al. Stability Constants for the Equilibrium Models of Iron(III) with Several Biological Buffers in Aqueous Solutions. Journal of Solution Chemistry, 2013; 42: 2296–2309.
[2] Gupta ;B, et al. Interactions of bovine serum albumin with biological buffers, TES, TAPS, and TAPSO in aqueous solutions. Process Biochemistry, 2013; 48: 1686-1696.
[3] Taha M, et al. New Insights into Buffer-Ionic Salt Interactions: Solubilities, Transfer Gibbs Energies, and Transfer Molar Volumes of TAPS and TAPSO from Water to Aqueous Electrolyte Solutions. Journal of Solution Chemistry, 2010; 39:1665–1680.

TAPSO(68399-81-5)Related Product Information

• Methyl salicylate
• Tribenuron methyl
• 2-METHYL-2-PROPENE-1-SULFONIC ACID SODIUM SALT
• 2-Hydroxyethanesulphonic acid
• Calcium dobesilate
• Methylparaben
• Sodium isethionate
• CHLOROPHOSPHONAZO III
• Kresoxim-methyl
• Tricine
• Methanol
• Methanesulfonic acid
• Tris(hydroxymethyl)aminomethane
• Tris(hydroxymethyl)nitromethane
• Methyl acrylate
• Methyl
• 3-[N-Tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic acid sodium salt
• Sulfurous Acid