Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) Chemical Properties

Melting point:

62-64°

Boiling point:

228.6±7.0 °C(Predicted)

Density 

1.01±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

12.74±0.20(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2924190090

Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis

Synthesis

Step 1. Dissolve cyclopropylamine (12.4 g, 252.2 mmol) in dichloromethane (50 mL) at 0°C and cool in an ice water bath. A solution of di-tert-butyl dicarbonate (43.7 g, 200 mmol) in dichloromethane (100 mL) was slowly added dropwise. After the dropwise addition, the reaction mixture was transferred to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation to afford N-Boc-cyclopropylamine (31 g, 99% yield).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2213 - 2236
[2] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 6, p. 1527 - 1536
[3] Patent: US2007/225280, 2007, A1. Location in patent: Page/Page column 17
[4] Monatshefte fur Chemie, 2017, vol. 148, # 12, p. 2143 - 2153
[5] Organic Letters, 2012, vol. 14, # 17, p. 4458 - 4461

Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI)(132844-48-5)Related Product Information

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