Cadrofloxacin
Cadrofloxacin Basic information
- Product Name:
- Cadrofloxacin
- Synonyms:
-
- Cadrofloxacin
- Caderofloxacin
- 1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-quinoline-3-carboxylic acid
- 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoroMethoxy)-6-fluoro-1,4-dihydro-7-[(3S)-3-Methyl-1-piperazinyl]-4-oxo-
- Cadrofloxacin USP/EP/BP
- CAS:
- 153808-85-6
- MF:
- C19H20F3N3O4
- MW:
- 411.38
- Mol File:
- 153808-85-6.mol
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Cadrofloxacin Chemical Properties
- Boiling point:
- 602.4±55.0 °C(Predicted)
- Density
- 1.458±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 10 mg/mL (24.31 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C)
- pka
- 6.40±0.50(Predicted)
- form
- Solid
- color
- White to off-white
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Cadrofloxacin Usage And Synthesis
Uses
Cadrofloxacin (Caderofloxacin; CS-940), a orally active fluoroquinolone, is effective against aerobic/anaerobic Gram-positive and Gram-negative bacteria. Cadrofloxacin can be used for the research of infectious diseases[1][2][3].
in vivo
Cadrofloxacin (9 mg/kg; i.g.; once or twice daily for 14 consecutive days) increases the activity of hepatic CYP2E1 in rats[2].
| Animal Model: | Male Sprague-Dawley rats weighing 180-220 g[2] |
| Dosage: | 9 mg/kg |
| Administration: | I.g. once or twice daily for 14 consecutive days |
| Result: | Enhanced the expression of hepatic CYP2E1 mRNA, inducing a 1.6-fold increase compared with that of control rats. The level of CYP2E1 protein in the hepatic microsomes was significantly higher than control group, 190% of that in control rats. |
References
[1] Biedenbach DJ, et al. Antimicrobial activity of CS-940, a new trifluorinated quinolone. Antimicrob Agents Chemother. 1995 Oct;39(10):2325-30. DOI:10.1128/AAC.39.10.2325
[2] Bryskier A, et al. Fluoroquinolones and tuberculosis. Expert Opin Investig Drugs. 2002 Feb;11(2):233-58. DOI:10.1517/13543784.11.2.233
CadrofloxacinSupplier
Nanjing Chemlin Chemical Co., Ltd
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SPIRO PHARMA
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