1H-Pyrrole-1-propanamide, N-[2-[2-[3-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo- Chemical Properties

Boiling point:

942.6±65.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

15.01±0.46(Predicted)

form 

Solid

color 

Yellow to brown

1H-Pyrrole-1-propanamide, N-[2-[2-[3-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo- Usage And Synthesis

Description

DBCO-PEG2-Maleimide is a PEG linker containing a DBCO moiety and a terminal primary maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-NHCO-PEG2-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-PEG2-maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

1H-Pyrrole-1-propanamide, N-[2-[2-[3-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo-(2698339-31-8)Related Product Information

• DBCO-PEG4-triethoxysilane
• Propanoic acid, 3-[2-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
• DBCO-PEG3-OH
• 4,7,10,13,16,19,22,25-Octaoxa-28-azadotricosanoic acid, 32-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-29,32-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
• DBCO-C6-acid
• DBCO-PEG2-amine
• DBCO-PEG4-maleimide
• DBCO-PEG3-Mal
• 4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
• DBCO-Acid
• DBCO-PEG1
• DBCO-PEG4-biotin
• DBCO-NHCO-PEG2-Biotin
• Ambient temperature
• DBCO-PEG4-Acid
• N-(6-aminocaproyl)azadibenzocyclooctyne