LAUROLITSINE Chemical Properties

Melting point:

138-140 ºC

Boiling point:

453.15°C (rough estimate)

Density 

1.313

refractive index 

1.5100 (estimate)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Cryst.

pka

9.81±0.20(Predicted)

color 

Off-white to pink

LAUROLITSINE Usage And Synthesis

Description

This noraporphiae alkaloid has been obtained from Litsea japonica and Neolitsea sericea and swells at 11 5-8°C before melting. It is dextrorotatory with [o:lbl + 102.5° (EtOH) and yields a picrate as yellow needles, m.p. 212°C (dec.) and a picrolonate, m.p. 239°C (dec.). The N-methyl derivative is identical with boldine.

Uses

Laurolitsine is an alkaloid extracted from Polyalthia longifolia var. pendula.

Definition

ChEBI: An isoquinoline alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV 1 integrase.

References

Nakasato, Nomura., Chem. Pharm. Bull., (Tokyo), 7, 780 (1959)
Kozuka., J. Ph arm. Soc., Japan, 82, 1567 (1962)
See also:
Johns, Lamberton., Austral. J. Chem., 20, 1277 (1967)

LAUROLITSINE(5890-18-6)Related Product Information

• Tetrahydropyran
• 5,6,7,8-TETRAHYDROISOQUINOLINE
• Tetrahydrofurfuryl alcohol
• (R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone
• Swertiamarine
• CYANIDIN CHLORIDE
• MONOCROTALINE
• (+)-Xanthoplanine
• Norglaucine hydrochloride
• 4H-Dibenzo(de,g)quinolin-9-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6 -methyl-, (S)-
• Boldine
• BOLDINE DIMETHYL ETHER
• BOLDINE HYDROCHLORIDE
• LAUROLITSINE
• laurotetanine
• Thalicarpine
• L-DICENTRINE
• AKOS 208-03