N-NITROSO-N-METHYLURETHANE Chemical Properties

Boiling point:

66 °C / 13mmHg

Density 

1,14 g/cm³

refractive index 

1.4360 to 1.4400

storage temp. 

Refrigerator

solubility 

Chloroform, Ethyl Acetate , Methanol

form 

Oil

pka

-2.73±0.70(Predicted)

color 

Clear Yellow

Water Solubility 

36.99g/L(24 ºC)

IARC

2B (Vol. 4, Sup 7) 1987

EPA Substance Registry System

N-Nitroso-N-methylurethane (615-53-2)

Safety Information

Risk Statements 

5-36/37/38-40

Safety Statements 

23-35-45-53

RIDADR 

2810

RTECS 

FC6300000

HS Code 

2924.19.8000

HazardClass 

1.1A

PackingGroup 

I

Hazardous Substances Data

615-53-2(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 180mg/kg

N-NITROSO-N-METHYLURETHANE Usage And Synthesis

Chemical Properties

Yellow Oil

Uses

N-Methyl-N-nitrosourethane is a nitrosamide which causes chromosomal damage in HeLa cells. It is also used in the synthesis of antifungal agents such as azoxybacillin.

Definition

ChEBI: N-Nitroso-N-methylurethane is a carboxylic ester.

General Description

Solid.

Reactivity Profile

N-NITROSO-N-METHYLURETHANE is a N-nitrosated carbamate ester. Incompatible with strong acids and bases. Especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen may be produced by the combination with active metals or nitrides Incompatible with oxidizing acids, peroxides, and hydroperoxides.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Experimental reproductive effects. Mutation data reported. Has been implicated as a transplacental brain carcinogen. Combustible when exposed to heat, sparks, open flame, and powerful oxidizers. Explodes when heated. A storage hazard. When heated to decomposition it emits toxic fumes of NOx.

N-NITROSO-N-METHYLURETHANE(615-53-2)Related Product Information

• N-NITROSO-N-ETHYLUREA
• N-NITROSODI-N-PROPYLAMINE
• 1-Methyl-1-nitrosourea
• N-METHYLURETHANE
• Urethane
• N-amyl-N-nitrosourethane
• N-(2-Chloroethyl)-N-nitroso-O-cyclohexylurethane
• 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone
• 2-CHLOROETHYL-N-NITROSOURETHANE
• 4-(carbethoxynitrosamino)-4-(3-pyridyl)butanal
• ETHYL ETHYLNITROSOCARBAMATE
• N-NITROSO-N-N-PROPYLURETHAN
• N-NITROSO-N-METHYLURETHANE