Irindalone
Irindalone Basic information
- Product Name:
- Irindalone
- Synonyms:
-
- Irindalone
- 1-[2-[4-[(1R)-3β-(4-Fluorophenyl)-2,3-dihydro-1H-inden-1α-yl]-1-piperazinyl]ethyl]-2-imidazolidinone
- Lu 21-?098
- 2-Imidazolidinone, 1-[2-[4-[(1R,3S)-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]ethyl]-
- CAS:
- 96478-43-2
- MF:
- C24H29FN4O
- MW:
- 408.518
- Mol File:
- 96478-43-2.mol
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Irindalone Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
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Irindalone Usage And Synthesis
Uses
Irindalone is a novel serotonin 5-HT2 antagonist.
in vivo
Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1].
IC 50
5-HT2 Receptor
References
[1] Mikkelsen EO, et al. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8. DOI:10.1016/0014-2999(88)90053-2
IrindaloneSupplier
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